Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches.
Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for rec...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 461; no. 5; pp. 561 - 571 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Nov2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104383875&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104383875 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Nov2012 vid: 461 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104383875 NLM23001328 2011754907 10.1007/s00428-012-1306-z NLM23001328 104383875 ppf: 561 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. aug: au: Romeo S Bovée JV Kroon HM Tirabosco R Natali C Zanatta L Sciot R Mertens F Athanasou N Alberghini M Szuhai K Hogendoorn PC Dei Tos AP Romeo, Salvatore Bovée, Judith V M G Kroon, Herman M Tirabosco, Roberto Natali, Cristina Zanatta, Lucia Sciot, Raf affil: Department of Pathology, Treviso Regional Hospital, Piazza Ospedale 1, 31100 Treviso, Italy sug: subj: Bone Neoplasms Diagnosis Neoplasms, Fibrous Tissue Diagnosis Adult Aged Aged, 80 and Over Bone Neoplasms Bone Neoplasms Metabolism Bone Neoplasms Mortality DNA Analysis Diagnosis, Differential Diagnostic Errors Europe Female Neoplasms, Fibrous Tissue Neoplasms, Fibrous Tissue Metabolism Neoplasms, Fibrous Tissue Mortality Prospective Studies Human In Situ Hybridization, Fluorescence Leiomyosarcoma Diagnosis Male Middle Age Osteosarcoma Diagnosis Rhabdomyosarcoma Diagnosis Tumor Markers, Biological Metabolism Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for reclassification and identification of histological subgroups with distinct clinical behaviour. A panel of immunostains was applied: smooth muscle actin, desmin, h-caldesmon, cytokeratin AE1-AE3, CD31, CD34, CD68, CD163, CD45, S100 and epithelial membrane antigen. Additional fluorescence in situ hybridisation and immunohistochemistry were performed whenever appropriate. All cases were reviewed by six bone and soft tissue pathologists and a consensus was reached. Follow-up for 43 patients (median 42 months, range 6-223 months) was available. Initial histological diagnosis was reformulated in 18 cases (26.8 %). Seven cases were reclassified as leiomyosarcoma, six as osteosarcoma, three as myxofibrosarcoma and one each as embryonal rhabdomyosarcoma and interdigitating dendritic cell sarcoma. One case showed a peculiar biphasic phenotype with epithelioid nests and myofibroblastic spindle cells. Among the remaining 48 cases, which met the WHO criteria for bone FS and bone MFH, we identified five subgroups. Seven cases were reclassified as undifferentiated pleomorphic sarcoma (UPS) and 11 as UPS with incomplete myogenic differentiation due to positivity for at least one myogenic marker. Six were reclassified as spindle cell sarcoma not otherwise specified. Among the remaining 24 cases, we identified a further two recurrent morphologic patterns: eight cases demonstrated a myoepithelioma-like phenotype and 16 cases a myofibroblastic phenotype. One of the myoepithelioma-like cases harboured a EWSR1-NFATC2 fusion. It appears that bone MFH and bone FS represent at best exclusion diagnoses. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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