Serrated polyps of the colon: how reproducible is their classification?
For several years, the lack of consensus on definition, nomenclature, natural history, and biology of serrated polyps (SPs) of the colon has created considerable confusion among pathologists. According to the latest WHO classification, the family of SPs comprises hyperplastic polyps (HPs), sessile s...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 461; no. 5; pp. 495 - 505 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104383878&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104383878 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Nov2012 vid: 461 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104383878 NLM23052370 2011754912 10.1007/s00428-012-1319-7 NLM23052370 104383878 ppf: 495 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Serrated polyps of the colon: how reproducible is their classification? aug: au: Ensari A Bilezikçi B Carneiro F Dogusoy GB Driessen A Dursun A Flejou JF Geboes K de Hertogh G Jouret-Mourin A Langner C Nagtegaal ID Offerhaus J Orlowska J Ristimäki A Sanz-Ortega J Savas B Sotiropoulou M Villanacci V Kursun N sug: subj: Adenoma Diagnosis Colonic Neoplasms Diagnosis Colonic Polyps Classification Adenoma Classification Colonic Neoplasms Classification Diagnosis, Differential Human Observer Bias Reproducibility of Results World Health Organization ab: For several years, the lack of consensus on definition, nomenclature, natural history, and biology of serrated polyps (SPs) of the colon has created considerable confusion among pathologists. According to the latest WHO classification, the family of SPs comprises hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs). The term SSA/P with dysplasia has replaced the category of mixed hyperplastic/adenomatous polyps (MPs). The present study aimed to evaluate the reproducibility of the diagnosis of SPs based on currently available diagnostic criteria and interactive consensus development. In an initial round, H&E slides of 70 cases of SPs were circulated among participating pathologists across Europe. This round was followed by a consensus discussion on diagnostic criteria. A second round was performed on the same 70 cases using the revised criteria and definitions according to the recent WHO classification. Data were evaluated for inter-observer agreement using Kappa statistics. In the initial round, for the total of 70 cases, a fair overall kappa value of 0.318 was reached, while in the second round overall kappa value improved to moderate (kappa = 0.557; p < 0.001). Overall kappa values for each diagnostic category also significantly improved in the final round, reaching 0.977 for HP, 0.912 for SSA/P, and 0.845 for TSA (p < 0.001). The diagnostic reproducibility of SPs improves when strictly defined, standardized diagnostic criteria adopted by consensus are applied. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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