The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis.
Purpose: In this study, we estimate the impact of a recent relapse on physical and mental health in subjects with relapsing-remitting multiple sclerosis (RRMS) using validated patient-reported outcome (PRO) measures.Methods: Subjects enrolled in the Comprehensive Longitudinal Investigation of MS at...
| Publicado en: | Quality of Life Research Vol. 21; no. 10; pp. 1677 - 1685 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104384396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104384396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Dec2012 vid: 21 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104384396 NLM22237991 2011755764 10.1007/s11136-011-0108-0 NLM22237991 104384396 ppf: 1677 ppct: 8 formats: fmt: @attributes: type: P tig: atl: The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis. aug: au: Healy BC Degano IR Schreck A Rintell D Weiner H Chitnis T Glanz BI Healy, Brian C Degano, Irene R Schreck, Ana Rintell, David Weiner, Howard Chitnis, Tanuja Glanz, Bonnie I affil: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA sug: subj: Mental Health Multiple Sclerosis Physiopathology Multiple Sclerosis Psychosocial Factors Quality of Life Adult Depression Diagnosis Fatigue Diagnosis Female Human Male Middle Age Prognosis Recurrence Severity of Illness Indices Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Purpose: In this study, we estimate the impact of a recent relapse on physical and mental health in subjects with relapsing-remitting multiple sclerosis (RRMS) using validated patient-reported outcome (PRO) measures.Methods: Subjects enrolled in the Comprehensive Longitudinal Investigation of MS at the Brigham and Women's Hospital with RRMS were eligible for enrollment. Subjects with a clinical visit within 45 days of a relapse were identified and divided into groups based on whether the relapse occurred before (recent relapse) (n = 59) or after the visit (pre-relapse) (n = 31). A group of subjects with no relapses was also identified (remission) (n = 336). PRO measures in these three groups were compared. All outcomes were compared using a t test and linear regression controlling for age, disease duration, sex, and EDSS.Results: Subjects with a recent relapse had significantly worse functioning on several physical and mental health scales compared to subjects in remission even after adjusting for potential confounders. Subjects with a recent relapse also showed significant deterioration on PRO measures over 1 year compared to subjects in remission (P < 0.05 for each comparison). Subjects in the pre-relapse group were not significantly different than subjects in remission.Conclusions: Clinical relapses have a measurable effect on PRO in subjects with RRMS. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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