Diagnosis of rejection after liver transplantation: use of phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS).
Background: In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31)P-MRS) provides non-invasive information about phospholipid metabolism.Aims: To delineate (31)P-MRS abnormalities in patients with chronic rejection and to characterize spectral changes by pathology.Patients and Methods: S...
| Publicado en: | Abdominal Imaging Vol. 37; no. 5; pp. 788 - 795 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104385322&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104385322 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09428925 O52 jtl: Abdominal Imaging issn: 09428925 maglogo: N pubinfo: dt: Oct2012 vid: 37 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104385322 104385322 NLM23166917 2011757289 NLM23166917 104385322 ppf: 788 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Diagnosis of rejection after liver transplantation: use of phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS). aug: au: Jiang T Liu S Xiao X Tao X Liu G Wang J Jiang, Tao Liu, Shiyuan Xiao, XiangSheng Tao, XiaoFeng Liu, GuangHua Wang, JinLin affil: Department of Radiology, Changzheng Hospital, The Second Military Medical University, Feng Yang Road 415, Shanghai, China sug: subj: Graft Rejection Liver Transplantation Magnetic Resonance Spectroscopy Methods Adult Biopsy Case Control Studies Female Human Image Interpretation, Computer Assisted Male Middle Age Phospholipids Metabolism Isotopes Diagnostic Use Nonparametric Statistics Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31)P-MRS) provides non-invasive information about phospholipid metabolism.Aims: To delineate (31)P-MRS abnormalities in patients with chronic rejection and to characterize spectral changes by pathology.Patients and Methods: Sixty-six liver transplant recipients (18 with chronic rejection and 48 with normal graft function) and 38 controls (23 healthy volunteers and fifteen patients with biliary duct stricture) were studied with in vivo (31)P-MRS. All the data and peak values were calibrated and calculated by the software of spectroscopy analysis GE, and the pH values were calculated by the Malloy's formula, then the peak area ratios and altitudes of metabolites relative to adenosine triphosphate (β-ATP)and phosphate (Pi) were measured.Results: (a) The peak area ratios and altitudes of PME and PDE in biliary duct stricture group and chronic rejection group were higher than those of healthy volunteer group and normal graft function group. Patients with chronic rejection had significant differences in the peak area ratios of PME: β-ATP (P < 0.05) and PDE: β-ATP (P < 0.05) and in the altitudes of PME: β-ATP (P < 0.05) as compared with the other groups. (b) The ratios of β-ATP/Pi decreased in biliary duct stricture group, while they increased in chronic rejection group. There was no difference between the four groups. There were similar changes in the ratios of PME/Pi, but there was significant difference between the chronic rejection group and the other three groups. (c) pH values increased in biliary duct stricture group and chronic rejection group, though the difference was not significant with the healthy control group. (d) Histological specimens showed focal loss of hepatocytes, degeneration, and hepatocytic atrophy.Conclusions: (31)P-MRS imaging is valuable in detecting the metabolism of the liver after transplantation, and suggests that further investigation of alterations in the phospholipid metabolism may be a useful future direction of research. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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