Analysis of Risk Factors for Extubation Failure in Subjects Submitted to Non-Emergency Elective Intracranial Surgery.

BACKGROUND: Extubation failure is defined as the re-institution of respiratory support ranging from 24 to 72 hours following scheduled extubation and occurs in 2% to 25% of extubated patients. The aim of this study was to determine clinical and surgical risk factors that may predict extubation failu...

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Publicado en:Respiratory Care Vol. 57; no. 12; pp. 2059 - 2067
Autores principales: Carlos Vidotto, Milena, Carrupt Machado Sogame, Luciana, Rodrigues Gazzotti, Mariana, Nelson Prandini, Mirto, Roberto Jardim, José
Formato: research tables/charts Journal Article
Publicado: Mary Ann Liebert, Inc. Dec2012
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2012
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      pub: Mary Ann Liebert, Inc.
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        atl: Analysis of Risk Factors for Extubation Failure in Subjects Submitted to Non-Emergency Elective Intracranial Surgery.
      aug:
        au:
          Carlos Vidotto, Milena
          Carrupt Machado Sogame, Luciana
          Rodrigues Gazzotti, Mariana
          Nelson Prandini, Mirto
          Roberto Jardim, José
        affil: Department of Physiotherapy, Universidade Federal de São Paulo, São Paulo, Brazil
      sug:
        subj:
          Craniotomy
          Postoperative Care
          Extubation
          Ventilator Weaning
          Treatment Failure
          Risk Factors
          Human
          Prospective Studies
          Nonexperimental Studies
          Descriptive Statistics
          Multivariate Analysis
          Female
          Male
          Sex Factors
          Fisher's Exact Test
          T-Tests
          Mann-Whitney U Test
          Logistic Regression
          Data Analysis Software
          Middle Age
          Middle Aged: 45-64 years
          Female
          Male
      ab: BACKGROUND: Extubation failure is defined as the re-institution of respiratory support ranging from 24 to 72 hours following scheduled extubation and occurs in 2% to 25% of extubated patients. The aim of this study was to determine clinical and surgical risk factors that may predict extubation failure in patients submitted to non-emergency intracranial surgery. METHODS: This was a prospective observational cohort study. The study was carried out on 317 subjects submitted to nonemergency intracranial surgery for tumors, aneurysms, and arteriovenous malformation. Preoperative assessment was performed and subjects were followed up for the determination of extubation failure until either discharge from hospital or death. RESULTS: Twenty-six (8.2%) of the 317 subjects experienced extubation failure following surgery. The following variables were considered for the multivariate analysis: level of consciousness at the time of extubation, duration of mechanical ventilation prior to extubation, sex and the use of intraoperative mannitol. The multivariate analysis determined that the most important variable for extubation failure was the level of consciousness at the time of extubation (P = .001), followed by female sex, which also showed to be significant (P = .006). CONCLUSIONS: Lower level of consciousness (GCS 8T-10T) and female sex were considered risk factors for extubation failure in subjects submitted to elective intracranial surgery.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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