(1)H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches.
Objective: To compare the diagnostic capability of proton ((1)H) magnetic resonance spectroscopy (MRS) in differentiating benign from malignant breast lesions on the basis of qualitative and quantitative approaches.Methods: We performed single-voxel (1)H MRS for 208 breast lesions, identified a clea...
| Publicado en: | European Radiology Vol. 23; no. 1; pp. 75 - 84 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104401597&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104401597 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2013 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104401597 84088353 NLM22777619 2011800230 10.1007/s00330-012-2555-6 NLM22777619 104401597 ppf: 75 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: (1)H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches. aug: au: Mizukoshi W Kozawa E Inoue K Saito N Nishi N Saeki T Kimura F Mizukoshi, Waka Kozawa, Eito Inoue, Kaiji Saito, Naoko Nishi, Naoko Saeki, Toshiaki Kimura, Fumiko affil: Department of Diagnostic Radiology, International Medical Center of Saitama Medical University, 1397-1 Yamane, Hidaka City, Saitama, Japan sug: subj: Breast Neoplasms Diagnosis Magnetic Resonance Spectroscopy Methods Adult Aged Breast Neoplasms Metabolism Choline Metabolism Contrast Media Diagnostic Use Diagnosis, Differential Female Human Mammography Middle Age ROC Curve Sensitivity and Specificity Nonparametric Statistics Ultrasonography Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Objective: To compare the diagnostic capability of proton ((1)H) magnetic resonance spectroscopy (MRS) in differentiating benign from malignant breast lesions on the basis of qualitative and quantitative approaches.Methods: We performed single-voxel (1)H MRS for 208 breast lesions, identified a clear total composite choline compounds (tCho) peak of signal-to-noise of ≥2 to represent malignancy (qualitative approach), and regarded tCho concentration equal to or greater than the cut-off value to represent malignancy (quantitative approach). We compared the diagnostic ability of both approaches using the Akaike information criterion (AIC) and McFadden's R (2).Results: Histologically, 169 lesions were malignant; 39 were benign. The qualitative approach demonstrated 84.6 % sensitivity and 51.3 % specificity for differentiating malignant and benign lesions. The mean tCho concentration was 1.13 mmol/kg for malignancy, 0.43 mmol/kg for benignity. The optimal cut-off point was 0.61 mmol/kg, use of which achieved 68.1 % sensitivity and 79.4 % specificity. Calculated AIC and R (2) score suggested the superiority of the quantitative approach for differentiating malignancy.Conclusions: Quantitative MRS provides higher specificity than qualitative MRS for differentiating malignant from benign lesions and could be more useful as an additional examination in routine breast MR imaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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