Does the use of hormonal contraceptives cause microstructural changes in cerebral white matter? Preliminary results of a DTI and tractography study.
Objective: To evaluate the effect of monophasic combined oral contraceptive pill (COCP) and menstrual cycle phase in healthy young women on white matter (WM) organization using diffusion tensor imaging (DTI).Methods: Thirty young women were included in the study; 15 women used COCP and 15 women had...
| Publicado en: | European Radiology Vol. 23; no. 1; pp. 57 - 65 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104401614&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104401614 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2013 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104401614 84088342 NLM22814829 2011800247 10.1007/s00330-012-2572-5 NLM22814829 104401614 ppf: 57 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Does the use of hormonal contraceptives cause microstructural changes in cerebral white matter? Preliminary results of a DTI and tractography study. aug: au: De Bondt T Van Hecke W Veraart J Leemans A Sijbers J Sunaert S Jacquemyn Y Parizel PM De Bondt, Timo Van Hecke, Wim Veraart, Jelle Leemans, Alexander Sijbers, Jan Sunaert, Stefan Jacquemyn, Yves Parizel, Paul M affil: Department of Radiology, University of Antwerp, Antwerp University Hospital, Wilrijkstraat 10, 2650, Antwerp, Belgium sug: subj: Brain Drug Effects Contraceptives, Oral Magnetic Resonance Imaging Methods Nerve Fibers Drug Effects Adolescence Algorithms Female Human Image Interpretation, Computer Assisted Menstrual Cycle Nonparametric Statistics Young Adult Adolescent: 13-18 years Female ab: Objective: To evaluate the effect of monophasic combined oral contraceptive pill (COCP) and menstrual cycle phase in healthy young women on white matter (WM) organization using diffusion tensor imaging (DTI).Methods: Thirty young women were included in the study; 15 women used COCP and 15 women had a natural cycle. All subjects underwent DTI magnetic resonance imaging during the follicular and luteal phase of their cycle, or in different COCP cycle phases. DTI parameters were obtained in different WM structures by performing diffusion tensor fibre tractography. Fractional anisotropy and mean diffusivity were calculated for different WM structures. Hormonal plasma concentrations were measured in peripheral venous blood samples and correlated with the DTI findings.Results: We found a significant difference in mean diffusivity in the fornix between the COCP and the natural cycle group. Mean diffusivity values in the fornix were negatively correlated with luteinizing hormone and estradiol blood concentrations.Conclusion: An important part in the limbic system, the fornix, regulates emotional processes. Differences in diffusion parameters in the fornix may contribute to behavioural alternations related to COCP use. This finding also suggests that the use of oral contraceptives needs to be taken into account when designing DTI group studies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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