Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers.
Objectives: To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.Methods: Forty-six patients with newly-developed/worsening symptoms aft...
| Publicado en: | European Radiology Vol. 23; no. 2; pp. 562 - 570 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104413590&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104413590 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2013 vid: 23 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104413590 NLM22865270 2011893872 10.1007/s00330-012-2596-x NLM22865270 104413590 ppf: 562 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers. aug: au: Tshering Vogel DW Zbaeren P Geretschlaeger A Vermathen P De Keyzer F Thoeny HC Tshering Vogel, Dechen W Zbaeren, Peter Geretschlaeger, Andreas Vermathen, Peter De Keyzer, Frederik Thoeny, Harriet C affil: Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland sug: subj: Carcinoma, Squamous Cell Diagnosis Magnetic Resonance Imaging Methods Head and Neck Neoplasms Diagnosis Hypopharyngeal Neoplasms Diagnosis Neoplasm Recurrence, Local Diagnosis Neoplastic Processes Diagnosis Aged Aged, 80 and Over Biopsy, Needle Carcinoma, Squamous Cell Mortality Carcinoma, Squamous Cell Therapy Prospective Studies Female Head and Neck Neoplasms Mortality Head and Neck Neoplasms Therapy Human Hypopharyngeal Neoplasms Mortality Hypopharyngeal Neoplasms Therapy Immunohistochemistry Laryngeal Neoplasms Diagnosis Laryngeal Neoplasms Mortality Laryngeal Neoplasms Therapy Male Middle Age Neoplasm Recurrence, Local Mortality Neoplasm Recurrence, Local Pathology Neoplastic Processes Mortality Neoplastic Processes Pathology Prognosis ROC Curve Risk Assessment Nonparametric Statistics Survival Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.Methods: Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC(T)], and bi-exponentially: perfusion fraction [F(P)] and true diffusion coefficient [ADC(D)]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney U test was used for statistical analysis.Results: Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC(T) and ADC(D) values were lower in tumour with values 120 ± 49 × 10(-5) mm(2)/s and 113 ± 50 × 10(-5) mm(2)/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10(-5) mm(2)/s (P < 0.0002) and 160 ± 47 × 10(-5) mm(2)/s (P < 0.003), respectively. F(P) values were significantly lower in tumours than in non-tumours (13 ± 9% versus 31 ± 16%, P < 0.0002), with F(P) being the best quantitative parameter for differentiation between post-therapeutic changes and recurrence.Conclusions: DW-MRI in combination with conventional MRI substantially improves detection and exclusion of tumour in patients with laryngeal and hypopharyngeal cancers after treatment with (chemo)radiotherapy on both qualitative and quantitative analysis, with F(P) being the best quantitative parameter in this context. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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