Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0 T in patients with early stage osteoarthritis.
Objectives: To assess the reproducibility of 3D delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 3 T in early stage knee osteoarthritis (OA) patients.Methods: In 20 patients, 3D dGEMRIC at 3 T was acquired twice within 7 days. To correct for patient motion during acquisition, all images wer...
| Publicado en: | European Radiology Vol. 23; no. 2; pp. 496 - 505 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104413600&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104413600 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2013 vid: 23 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104413600 NLM22886535 2011893881 10.1007/s00330-012-2616-x NLM22886535 104413600 ppf: 496 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0 T in patients with early stage osteoarthritis. aug: au: van Tiel J Bron EE Tiderius CJ Bos PK Reijman M Klein S Verhaar JA Krestin GP Weinans H Kotek G Oei EH van Tiel, J Bron, E E Tiderius, C J Bos, P K Reijman, M Klein, S Verhaar, J A N Krestin, G P Weinans, H affil: Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands sug: subj: Cartilage, Articular Pathology Contrast Media Diagnostic Use Diagnostic Imaging Magnetic Resonance Imaging Methods Osteoarthritis, Knee Diagnosis Adult Prospective Studies Female Human Image Enhancement Methods Male Middle Age Prognosis Reproducibility of Results Sensitivity and Specificity Severity of Illness Indices Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: To assess the reproducibility of 3D delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 3 T in early stage knee osteoarthritis (OA) patients.Methods: In 20 patients, 3D dGEMRIC at 3 T was acquired twice within 7 days. To correct for patient motion during acquisition, all images were rigidly registered in 3D. Eight anatomical cartilage ROIs were analysed on both images of each patient. Capability of dGEMRIC to yield T1 maps that reproducibly distinguish spatial differences in cartilage quality was assessed in two ROIs within a single slice in each patient. Reproducibility was assessed using ICCs and Bland-Altman plots.Results: ICCs ranged from 0.87 to 0.95, indicating good reproducibility. T1 maps revealed reproducible spatial differences in cartilage quality (ICC 0.79). Based on the Bland-Altman plots, we defined a threshold of 95 ms to determine if a change in dGEMRIC outcome in longitudinal research was statistically significant.Conclusions: 3D knee dGEMRIC at 3 T combined with 3D image registration is a highly reproducible measure of cartilage quality in early stage OA. Therefore, dGEMRIC may be a valuable tool in the non-invasive evaluation of cartilage quality changes in longitudinal research in patients with early stage OA and focal cartilage defects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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