Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter.
Objectives: Seven-Tesla MRI demonstrated new pathological features of multiple sclerosis (MS) using T2-weighted sequences. However, a clinical MRI protocol at 7 T has never been investigated. We evaluated the clinical value of 7-T MRI by investigating the sensitivity of lesion detection compared wit...
| Publicado en: | European Radiology Vol. 23; no. 2; pp. 528 - 541 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104413606&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104413606 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2013 vid: 23 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104413606 NLM22898935 2011893887 10.1007/s00330-012-2619-7 NLM22898935 104413606 ppf: 528 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter. aug: au: de Graaf WL Kilsdonk ID Lopez-Soriano A Zwanenburg JJ Visser F Polman CH Castelijns JA Geurts JJ Pouwels PJ Luijten PR Barkhof F Wattjes MP de Graaf, Wolter L Kilsdonk, Iris D Lopez-Soriano, Alexandra Zwanenburg, Jaco J M Visser, Fredy Polman, Chris H Castelijns, Jonas A Geurts, Jeroen J G affil: Department of Radiology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands sug: subj: Cerebral Cortex Pathology Contrast Media Diagnostic Use Diagnostic Imaging Magnetic Resonance Imaging Methods Multiple Sclerosis Diagnosis Adult Aged Case Control Studies Female Human Image Enhancement Methods Image Processing, Computer Assisted Male Middle Age Prospective Studies Reference Values Reproducibility of Results Sensitivity and Specificity Severity of Illness Indices Nonparametric Statistics Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: Seven-Tesla MRI demonstrated new pathological features of multiple sclerosis (MS) using T2-weighted sequences. However, a clinical MRI protocol at 7 T has never been investigated. We evaluated the clinical value of 7-T MRI by investigating the sensitivity of lesion detection compared with 3 T.Methods: Thirty-eight MS patients and eight healthy controls underwent multi-contrast MRI using 3D T1-weighted (3D-T1w), 2D dual-echo T2-weighted (2D-T2w) and 3D fluid-attenuated inversion recovery (3D-FLAIR) at 3 and 7 T. Images were analysed for focal lesions, which were counted and categorised according to anatomical location. The study was approved by the institutional review board.Results: Lesion-wise analysis showed increased lesion counts in cortical grey matter (GM) at 7 T of 91, 75 and 238 % for 3D-T1w, 2D-T2w and FLAIR sequences, respectively. Patient-wise analysis confirmed this for 2D-T2w and FLAIR (P < 0.023 and P < 0.001). Seven-Tesla white matter (WM) lesion detection was not increased; 3D-FLAIR even detected significantly more WM lesions at 3 T.Conclusions: Using a clinical multi-contrast MRI protocol, increased lesion detection was observed in cortical GM but not in WM. Given the clinical relevance of GM abnormalities, this may have consequences for clinical outcome measures, prognostic classification and future diagnostic criteria incorporating GM abnormalities. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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