Fat deposition decreases diffusion parameters at MRI: a study in phantoms and patients with liver steatosis.
Purpose: Assess the effect of fat deposition on the MRI diffusion coefficients in lipid emulsion-based phantoms and patients with proven isolated liver steatosis.Materials and Methods: Diffusion-weighted MRI with 11 b values from 0-500 s/mm(2) was performed in phantoms (fat fractions 0-18 %) with an...
| Publicado en: | European Radiology Vol. 23; no. 2; pp. 461 - 468 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104413618&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104413618 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2013 vid: 23 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104413618 NLM22935901 2011893899 10.1007/s00330-012-2626-8 NLM22935901 104413618 ppf: 461 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Fat deposition decreases diffusion parameters at MRI: a study in phantoms and patients with liver steatosis. aug: au: Leitao HS Doblas S d'Assignies G Garteiser P Daire JL Paradis V Geraldes CF Vilgrain V Van Beers BE Leitão, Helena S Doblas, Sabrina d'Assignies, Gaspard Garteiser, Philippe Daire, Jean-Luc Paradis, Valérie Geraldes, Carlos F G C Vilgrain, Valérie Van Beers, Bernard E affil: Center for Neuroscience and Cell Biology, PhD Program in Experimental Biology and Biomedicine, University of Coimbra, Coimbra, Portugal sug: subj: Adipose Tissue Pathology Magnetic Resonance Imaging Methods Fatty Liver Diagnosis Phantoms, Imaging Adipose Tissue Metabolism Adult Aged Case Control Studies Female Human Male Middle Age Reference Values Sensitivity and Specificity Nonparametric Statistics Young Adult Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: Assess the effect of fat deposition on the MRI diffusion coefficients in lipid emulsion-based phantoms and patients with proven isolated liver steatosis.Materials and Methods: Diffusion-weighted MRI with 11 b values from 0-500 s/mm(2) was performed in phantoms (fat fractions 0-18 %) with and without fat suppression and in 19 patients with normal liver (n = 14) or isolated liver steatosis (n = 5) proven by histopathology. The apparent, pure and perfusion-related diffusion coefficients and the perfusion fraction were measured. Spearman correlation coefficient and Mann-Whitney U test were used for comparisons.Results: A strong correlation between the apparent and pure diffusion coefficients and fat fractions was seen in phantoms. The pure diffusion coefficient decreased significantly in patients with liver steatosis (0.96 ± 0.16 × 10(-3) mm(2)/s versus 1.18 ± 0.09 × 10(-3) mm(2)/s in normal liver, P = 0.005), whereas the decrease in apparent diffusion coefficient did not reach statistical significance (1.26 ± 0.25 × 10(-3) mm(2)/s versus 1.41 ± 0.14 × 10(-3) mm(2)/s in normal liver, P = 0.298).Conclusions: Fat deposition decreases the apparent and pure diffusion coefficients in lipid emulsion-based phantoms and patients with isolated liver steatosis proven by histopathology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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