Sex differences in decreased limbic and cortical grey matter volume in cocaine dependence: a voxel-based morphometric study.
Structural neuroimaging studies have provided evidence of differences in local brain volume between cocaine-dependent and healthy control individuals. While sex differences in aetiology, course and brain dysfunction associated with chronic cocaine abuse have been previously documented, evidence of s...
| Publicado en: | Addiction Biology Vol. 18; no. 1; pp. 147 - 161 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104414135&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104414135 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13556215 ADB jtl: Addiction Biology issn: 13556215 maglogo: Y pubinfo: dt: Jan2013 vid: 18 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104414135 NLM23167305 2011894603 10.1111/adb.12008 NLM23167305 PMC3651026 104414135 ppf: 147 ppct: 14 formats: tig: atl: Sex differences in decreased limbic and cortical grey matter volume in cocaine dependence: a voxel-based morphometric study. aug: au: Rando K Tuit K Hannestad J Guarnaccia J Sinha R Rando, Kenneth Tuit, Keri Hannestad, Jonas Guarnaccia, Joseph Sinha, Rajita affil: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA sug: subj: Brain Pathology Substance Use Disorders Adult Alcohol Drinking Animals Case Control Studies Cerebral Cortex Pathology Cluster Analysis Female Limbic System Pathology Hippocampus Pathology Human Image Processing, Computer Assisted Methods Linear Regression Magnetic Resonance Imaging Methods Male Middle Age Neuroradiography Methods Neuroradiography Statistics and Numerical Data Reproduction Sex Factors Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Structural neuroimaging studies have provided evidence of differences in local brain volume between cocaine-dependent and healthy control individuals. While sex differences in aetiology, course and brain dysfunction associated with chronic cocaine abuse have been previously documented, evidence of sex-specific differences in brain volume has not been examined thus far. This study examined sex-related differences in grey matter volume between cocaine-dependent and healthy control subjects using voxel-based morphometry. High-resolution T1 structural scans were obtained from 36 inpatient, treatment-engaged 3-week abstinent cocaine-dependent (CD) individuals. Fifty healthy control subjects were also scanned. Segmentation and registration were performed in SPM8, using New Segment and DARTEL, respectively. The whole-brain statistical analysis was conducted in SPM8 using random field-based cluster-size testing and family-wise error rate correction for multiple comparisons. CD patients were found to have less grey matter volume in anterior prefrontal cortex, including frontopolar and orbitofrontal cortices, and a posterior region surrounding the parietal-occipital sulcus. Female CD patients had less grey matter volume than female controls in left inferior frontal gyrus, insula, superior temporal gyrus and hippocampus. Male CD patients had less grey matter in a superior cortical region that included the precentral gyrus and the mid-cingulate. These sex differences in lower grey matter volume add to the evidence from functional neuroimaging for sex-specific differences in the neurophysiological changes associated with chronic cocaine use. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|