Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI.
Background: Small-bowel MRI based on contrast-enhanced T1-weighted sequences has been challenged by diffusion-weighted imaging (DWI) for detection of inflammatory bowel lesions and complications in patients with Crohn disease.Objective: To evaluate free-breathing DWI, as compared to contrast-enhance...
| Published in: | Pediatric Radiology Vol. 43; no. 1; pp. 103 - 115 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jan2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104414674&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104414674 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jan2013 vid: 43 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104414674 NLM23212595 2011895599 10.1007/s00247-012-2492-1 NLM23212595 104414674 ppf: 103 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI. aug: au: Neubauer H Pabst T Dick A Machann W Evangelista L Wirth C Köstler H Hahn D Beer M Neubauer, Henning Pabst, Thomas Dick, Anke Machann, Wolfram Evangelista, Laura Wirth, Clemens Köstler, Herbert Hahn, Dietbert Beer, Meinrad affil: Institute of Radiology, Department of Paediatric Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080, Wuerzburg, Germany sug: subj: Contrast Media Crohn Disease Pathology Magnetic Resonance Imaging Intestine, Small Pathology Magnetic Resonance Imaging Methods Adolescence Adult Case Control Studies Child Colonoscopy Female Human Lymphatic Diseases Pathology Male Retrospective Design Young Adult Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Female Male ab: Background: Small-bowel MRI based on contrast-enhanced T1-weighted sequences has been challenged by diffusion-weighted imaging (DWI) for detection of inflammatory bowel lesions and complications in patients with Crohn disease.Objective: To evaluate free-breathing DWI, as compared to contrast-enhanced MRI, in children, adolescents and young adults with Crohn disease.Materials and Methods: This retrospective study included 33 children and young adults with Crohn disease ages 17 ± 3 years (mean ± standard deviation) and 27 matched controls who underwent small-bowel MRI with contrast-enhanced T1-weighted sequences and DWI at 1.5 T. The detectability of Crohn manifestations was determined. Concurrent colonoscopy as reference was available in two-thirds of the children with Crohn disease.Results: DWI and contrast-enhanced MRI correctly identified 32 and 31 patients, respectively. All 22 small-bowel lesions and all Crohn complications were detected. False-positive findings (two on DWI, one on contrast-enhanced MRI), compared to colonoscopy, were a result of large-bowel lumen collapse. Inflammatory wall thickening was comparable on DWI and contrast-enhanced MRI. DWI was superior to contrast-enhanced MRI for detection of lesions in 27% of the assessed bowel segments and equal to contrast-enhanced MRI in 71% of segments.Conclusion: DWI facilitates fast, accurate and comprehensive workup in Crohn disease without the need for intravenous administration of contrast medium. Contrast-enhanced MRI is superior in terms of spatial resolution and multiplanar acquisition. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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