Interstitial lung diseases-can pathologists arrive at an etiology-based diagnosis? A critical update.
Interstitial lung diseases (ILD) encompass a group of diseases with a wide range of etiologies and a variety of tissue reactions within the lung. In many instances, a careful evaluation of the tissue reactions will result in a specific diagnosis or at least in a narrow range of differentials, which...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 462; no. 1; pp. 1 - 27 |
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| Autores principales: | , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Jan2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104414688&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104414688 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Jan2013 vid: 462 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104414688 NLM23224047 2011895615 10.1007/s00428-012-1305-0 NLM23224047 104414688 ppf: 1 ppct: 26 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Interstitial lung diseases-can pathologists arrive at an etiology-based diagnosis? A critical update. aug: au: Popper HH Popper, Helmut H affil: Research Unit for Molecular Lung and Pleura Pathology, Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, 8036, Austria sug: subj: Lung Diseases, Interstitial Diagnosis Lung Diseases, Interstitial Etiology Algorithms Hypertension, Pulmonary Diagnosis Hypertension, Pulmonary Etiology Immunity Immunology Lung Diseases, Interstitial Classification Lung Injury Chemically Induced Lung Injury Diagnosis Drugs Adverse Effects Pneumoconiosis Diagnosis Pneumoconiosis Etiology Pulmonary Fibrosis Diagnosis Pulmonary Fibrosis Etiology ab: Interstitial lung diseases (ILD) encompass a group of diseases with a wide range of etiologies and a variety of tissue reactions within the lung. In many instances, a careful evaluation of the tissue reactions will result in a specific diagnosis or at least in a narrow range of differentials, which will assist the clinician to arrive at a definite diagnosis, when combining our interpretation with the clinical presentation of the patient and high-resolution computed tomography. In this review, we will exclude granulomatous pneumonias as well as vascular diseases (primary arterial pulmonary hypertension and vasculitis); however, pulmonary hypertension as a complication of interstitial processes will be mentioned. Few entities of pneumoconiosis presenting as an interstitial process will be included, whereas those with granulomatous reactions will be excluded. Drug reactions will be touched on within interstitial pneumonias, but will not be a major focus. In contrast to the present-day preferred descriptive pattern recognition, it is the author's strong belief that pathologists should always try to dig out the etiology from a tissue specimen and not being satisfied with just a pattern description. It is the difference of sorting tissue reactions into boxes by their main pattern, without recognizing minor or minute reactions, which sometimes will guide one to the correct etiology-oriented interpretation. In the author's personal perspective, tissue reactions can even be sorted by their timeliness, and therefore, ordered by the time of appearance, providing an insight into the pathogenesis and course of a disease. Also, underlying immune mechanisms will be discussed briefly as far as they are essential to understand the disease. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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