Rheumatic and Autoimmune Diseases May Have a Role in Disease Progression of Myelodysplastic Syndrome.
Objective: Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder that leads to underproduction of normal blood cells. It causes dysgenesis of the blood cells. The cause of de novo MDS is not known. About 10% of cases of MDS are secondary, most often due to radiation treatment or chemothera...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 4; pp. 910 - 917 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Aug2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104415874&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104415874 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Aug2012 vid: 32 iid: 4 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104415874 2011681415 10.5336/medsci.2011-24201 104415874 ppf: 910 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Rheumatic and Autoimmune Diseases May Have a Role in Disease Progression of Myelodysplastic Syndrome. aug: au: Kozan, Salih Torun, Deniz Tunca, Yusuf Beyan, Cengiz Ifran, Ahmet Kaptan, M. Kürsat Ural, Ali Ugur Nevruz, Oral Avcu, Ferit Çetin, A. Türker Kürekçi, Ahmet Emin Gül, Davut Terzi, Yunus Kasim Çoban, Zehra Dilsad Bahçe, Muhterem Güran, Sefik affil: Department of Medical Genetics, Gülhane Military Medical Academy, Ankara sug: subj: Arthritis, Rheumatoid Complications Autoimmune Diseases Complications Disease Progression Myelodysplastic Syndromes Adolescence Adult Aged Aged, 80 and Over Case Control Studies Child Female Fisher's Exact Test Human Male Middle Age Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Child: 6-12 years Middle Aged: 45-64 years Female Male ab: Objective: Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder that leads to underproduction of normal blood cells. It causes dysgenesis of the blood cells. The cause of de novo MDS is not known. About 10% of cases of MDS are secondary, most often due to radiation treatment or chemotherapy for cancer. The role of other diseases observed in the patients and their families is not clear in the progression of MDS. Here, the diseases observed in our series (71 MDS cases and their families) were compared with the normal controls (71 normal cases and their families) to understand the affect of other diseases in the progression of MDS. Material and Methods: Among 71 MDS cases, 29 cases with refractory cytopenia with unilineage dysplasia, one cases with refractory anemia with ring sideroblast, 28 cases with refractory cytopenias with multilineage dysplasia, 11 cases with refractory anemia with excess blasts and 2 cases with MDS associated with isolated del (5q) were diagnosed with clinical and laboratory results. The diseases in MDS and the control groups were classified according to general classifications. Results: The numbers of affected patients in each group represented no significant difference between MDS and the control groups. According to these results, no correlation was found between the other diseases and MDS group. As known, some diseases have an accumulation in some families representing genetic predisposition. In order to find out the role of such systemic diseases frequently observed in one family, two groups were compared. In this group, the families which had two or more affected cases with the same diagnoses were accounted. Twenty six families had similar two or more diseases in MDS group whereas 21 families had similar two or more diseases in the control group. The difference between the MDS group (8 families) and the control group (2 families) which had rheumatic and autoimmune diseases were noticed. The number of affected families in MDS group with rheumatic and autoimmune diseases was greater than the number of affected families in the control group (p = 0.049). Conclusion: Our results may represent the possible role of rheumatic and autoimmune diseases in MDS etiology. Further findings are needed which represent the predisposition of rheumatic and autoimmune conditions in MDS progression. Key Words: Myelodysplastic syndromes pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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