Relationship Between Hemochromatosis Gene Mutations and Degree of Fibrosis in Liver Disease Associated with Chronic Hepatitis B and C.
Objective: There are various factors that affect the degree of liver fibrosis in chronic viral hepatitis (CVH). Deposition of iron in the liver is one of these factors. Although hemochromatosis gene (HFE) mutation is determined as heterozygote, it is thought that it causes deposition of iron in the...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 4; pp. 917 - 925 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104415875&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104415875 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Aug2012 vid: 32 iid: 4 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104415875 2011681416 10.5336/medsci.2011-24436 104415875 ppf: 917 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Relationship Between Hemochromatosis Gene Mutations and Degree of Fibrosis in Liver Disease Associated with Chronic Hepatitis B and C. aug: au: Bagir, Gülay Simsek Dogan, Ümit Bilge Egesel, Türker Canataroglu, Abdullah affil: Clinic of Internal Medicine, Adana Numune Training and Research Hospital, Adana sug: subj: Chronic Disease Fibrosis Risk Factors Genes Hemochromatosis Familial and Genetic Hepatitis B Complications Hepatitis C Complications Mutation Adolescence Adult Aged Aged, 80 and Over Alanine Aminotransferase Blood Aspartate Aminotransferase Blood Case Control Studies Data Analysis Software Descriptive Statistics Female Ferritin Blood Human Iron Blood Kruskal-Wallis Test Male Mann-Whitney U Test Middle Age One-Way Analysis of Variance Pearson's Correlation Coefficient T-Tests Transferrin Blood Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: There are various factors that affect the degree of liver fibrosis in chronic viral hepatitis (CVH). Deposition of iron in the liver is one of these factors. Although hemochromatosis gene (HFE) mutation is determined as heterozygote, it is thought that it causes deposition of iron in the liver. However, the effect of the deposition of iron as a result of HFE gene mutation that leads to the progression of fibrosis in patients with CVH is still uncertain. The purpose of this study is to evaluate the association of HFE gene mutations with serum iron indices and degree of fibrosis in patients with CVH. Material and Methods: The study enrolled 83 patients with chronic hepatitis B, 61 patients with chronic hepatitis C and 50 healthy controls. Fifty-two of the patients also had cirrhosis. AST, ALT, serum iron, ferritin and transferrin saturations were measured and the presence of HFE mutations were investigated for all individuals. Liver biopsy was performed to all patients. Histopathological findings in the liver were scored as necroinflammatory activity and fibrosis according to the Knodell scoring scale. Results: The C282Y mutations could not be detected in any individuals. H63D heterozygous and homozygous mutations were found but they did not differ between patients (n=29, 20.1%) and controls (n=14, 28%). Presence of H63D mutations was not associated with serum iron indices or the degree of hepatic fibrosis. Conclusion:Our results showed that H63D gene mutations do not have a significant role in the progression of fibrosis in CVH. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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