The Effect of Heavy Metals and Trace Elements in the Meconium on Preterm Delivery of Unknown Etiology.

Objective: Prematurity is an important etiologic factor for perinatal mortality and morbidity. In our country, preterm births and complications of prematurity account for 26% of perinatal mortality. There are many maternal, fetal or placental, genetic and environmental etiologic factors that cause p...

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Publicado en:Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 4; pp. 925 - 932
Autores principales: Özsoy, Gamze, Türker, Gülcan, Özdemir, Semra, Gökalp, Ayse Sevim, Barutçu, Ümit Bora
Formato: research tables/charts Journal Article
Publicado: Turkiye Klinikleri Aug2012
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2012
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        atl: The Effect of Heavy Metals and Trace Elements in the Meconium on Preterm Delivery of Unknown Etiology.
      aug:
        au:
          Özsoy, Gamze
          Türker, Gülcan
          Özdemir, Semra
          Gökalp, Ayse Sevim
          Barutçu, Ümit Bora
        affil: Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli
      sug:
        subj:
          Childbirth, Premature Risk Factors
          Meconium
          Metals, Heavy Adverse Effects
          Trace Elements
          Cadmium Analysis
          Case Control Studies
          Chi Square Test
          Data Analysis Software
          Human
          Infant, Newborn
          Kruskal-Wallis Test
          Lead Analysis
          Mann-Whitney U Test
          Post Hoc Analysis
          Infant, Newborn: birth-1 month
      ab: Objective: Prematurity is an important etiologic factor for perinatal mortality and morbidity. In our country, preterm births and complications of prematurity account for 26% of perinatal mortality. There are many maternal, fetal or placental, genetic and environmental etiologic factors that cause prematurity. There have been no studies to show an association between preterm delivery of unknown etiology and exposure to heavy metals and trace elements at toxic levels in meconium. The purpose of this study is to measure the levels of heavy metals (lead, cadmium) and trace elements (zinc, iron, copper) in meconium samples and to understand their associations with preterm delivery of unknown etiology. Material and Methods: The levels of heavy metals and trace elements in the meconiums of 810 term or preterm infants with known and unknown etiology for being preterm were measured with a flame atomic absorption spectrophotometer. Results: Lead and cadmium were detected in all meconium samples. Heavy metal and trace element levels in meconium were significantly higher in preterms of unknown and known etiology for being preterm compared to term infants (for all p<0.0001). Lead levels in meconium were significantly higher in preterm of unknown etiology compared to preterm of known etiology in posthoc analysis with Bonferroni corrected Mann Whitney U test. Conclusion: These results may suggest that lead levels in meconium samples are higher in preterm newborns especially with unknown etiology compared to term newborns. Therefore, we suggest that preterm delivery of unknown etiology may be decreased by decreasing air pollution.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: Turkish
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