Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy.
Objective: This study was conducted to evaluate the efficacy of pre-emptive pregabalin compared with plasebo and diclofenac combination for attenuating postoperative pain, analgesic consumption and cognitive function after laparoscopic cholecystectomy. Material and Methods: Sixty adults with ASA phy...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 4; pp. 963 - 971 |
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| Autores principales: | , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Turkiye Klinikleri
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104415881&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104415881 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Aug2012 vid: 32 iid: 4 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104415881 2011681422 10.5336/medsci.2011-25368 104415881 ppf: 963 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy. aug: au: Akarsu, Tülin Tür, Hülya Bolat, Cihan Özkaynak, Ismail affil: Clinic of Anesthesiology and Reanimation, Kartal Kosuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul sug: subj: Cholecystectomy Adverse Effects Diclofenac Therapeutic Use Drug Therapy, Combination Laparoscopy Methods Postoperative Pain Prevention and Control Pregabalin Therapeutic Use Premedication Adult Aged Chi Square Test Data Analysis Software Descriptive Statistics Female Fisher's Exact Test Goodness of Fit Chi Square Test Human Male Mann-Whitney U Test McNemar's Test Middle Age Post Hoc Analysis Randomized Controlled Trials Scales Visual Analog Scaling Wilcoxon Signed Rank Test Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: This study was conducted to evaluate the efficacy of pre-emptive pregabalin compared with plasebo and diclofenac combination for attenuating postoperative pain, analgesic consumption and cognitive function after laparoscopic cholecystectomy. Material and Methods: Sixty adults with ASA physical status I-III of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, single-blind study. Subjects were divided into two groups being 30 pat.ents in each to receive either a matching placebo or pregabalin 300 mg, administered orally 1 h before surgery. Intramuscular 75 mg diclofenac sodium was given to placebo patients 15-20 minutes before the estimated finishing time of surgery for pain relief after surgery. In the first 15 minutes after extubation, Aldrete Score and Ramsay Sedation Scale were evaluated. Mini mental test (MMT) was performed 1 hour and 6 hours after extubation. Postoperative pain was assessed by visual analogue scale (VAS). Time to first analgesic requirement, total analgesic dose and side effects were recorded. Results: The difference between preoperative 1st h and 6th h MMT values was not statistically significant between the two groups. VAS scores were significantly higher in Group C compared to Group P (p <0.01). In Group P, the time to first analgesic rescue dose was significantly longer than in Group C (p<0.01). Total analgesic doses were significantly lower than in Group C patients (p<0.01). Sedation was significantly higher in Group P (p<0.05). Conclusion: We conclude that administration of 300 mg of pregabalin 1 hour before surgery lengthens recovery time minimally, prolongs first analgesic requirement time, reduces total analgesic consumption and does not impair cognitive functions. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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