The Rate of Spontaneous Hepatitis B Surface Antigen Seroclearance in Inactive Hepatitis B Carriers: A Study from Medium Endemic Area.
Objective: In this study, we aimed to determine the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance in inactive chronic hepatitis B virus (HBV) carriers. We compared demographic and laboratory characteristics between the patients with and without seroclearance. Material and Met...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 4; pp. 1039 - 1043 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Aug2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104415890&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104415890 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Aug2012 vid: 32 iid: 4 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104415890 2011681432 10.5336/medsci.2011-26744 104415890 ppf: 1039 ppct: 4 formats: fmt: @attributes: type: P tig: atl: The Rate of Spontaneous Hepatitis B Surface Antigen Seroclearance in Inactive Hepatitis B Carriers: A Study from Medium Endemic Area. aug: au: Köse, Sükran Tatar, Bengü Gireniz Ulusoy, Melda Türken Akkoçlu, Gülgün affil: Department of Infectious Diseases and Clinical Microbiology, Tepecik Training and Research Hospital, Izmir sug: subj: Antigens Carrier State Hepatitis B Immunology Academic Medical Centers Adolescence Adult Aged Alanine Aminotransferase Blood Antibodies Blood Data Analysis Software Descriptive Statistics DNA Blood Female Human Male Mann-Whitney U Test Middle Age Retrospective Design Turkiye Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: In this study, we aimed to determine the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance in inactive chronic hepatitis B virus (HBV) carriers. We compared demographic and laboratory characteristics between the patients with and without seroclearance. Material and Methods: This study included retrospective evaluation of 2428 patients with chronic hepatitis B (CHB). The patients with HBsAg positivity for at least 6 months with HBV-DNA levels lower than 104 copies/ml, with normal serum alanine transaminase (ALT) levels, negative for HBeAg, and with detectable anti-HBe antibodies were enrolled in the study. HBsAg seroclearence rates were determined, and the groups with and without seroclearance were compared in demographic and laboratory aspects. Results: The annual rate of spontaneous HBsAg seroclearance in the study group was 0.17%. Among patients with seroclearance, the annual rate of seroconversion was 1%. There was no statistically significant difference between groups for demographic characteristics. HBV DNA levels were significantly lower in patients with seroclearance (p<0.001). Conclusion: This study revealed that annual HBsAg seroclearance rate in inactive chronic HBV infection was 0.17% after 11 years of follow-up. The rate may increase with longer duration of follow-up. The association with viral/host genotypes and seroclearence rate demands further analysis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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