Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: A critical role of endothelial nitric oxide synthase.
Low-energy extracorporeal shock wave ( LE- ESW) treatment has been shown to accelerate wound repair; however, the mechanisms of treatment remain unclear. In the present study, we addressed the role of endothelial nitric oxide synthase ( eNOS). A single LE- ESW treatment accelerated the healing of wo...
| Publicado en: | Wound Repair & Regeneration Vol. 20; no. 6; pp. 887 - 896 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov/Dec2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104433881&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104433881 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Nov/Dec2012 vid: 20 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104433881 83167812 10.1111/j.1524-475X.2012.00851.x NLM23110611 104433881 ppf: 887 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: A critical role of endothelial nitric oxide synthase. aug: au: Hayashi, Denso Kawakami, Kazuyoshi Ito, Kenta Ishii, Keiko Tanno, Hiromasa Imai, Yoshimichi Kanno, Emi Maruyama, Ryoko Shimokawa, Hiroaki Tachi, Masahiro affil: Department of Plastic and Reconstructive Surgery, Tohoku University Graduate School of Medicine sug: subj: Lithotripsy Wound Healing Skin Diabetes Mellitus Endothelium Physiology Enzymes Nitric Oxide Metabolism Animal Studies Mice Models, Biological Funding Source Growth Substances Immunohistochemistry Blotting, Western Reverse Transcriptase Polymerase Chain Reaction Descriptive Statistics T-Tests Data Analysis Software ab: Low-energy extracorporeal shock wave ( LE- ESW) treatment has been shown to accelerate wound repair; however, the mechanisms of treatment remain unclear. In the present study, we addressed the role of endothelial nitric oxide synthase ( eNOS). A single LE- ESW treatment accelerated the healing of wounds in diabetic mice caused by the injection of streptozotocin. This accelerated healing was accompanied by the increased expression of eNOS and vascular endothelial growth factor ( VEGF) and the generation of new vessels at the wound tissues. These results raised the possibility that eNOS may be involved in the beneficial effects of LE- ESW treatment. To address this possibility, we compared the effects of this treatment between mice with a genetic disruption of eNOS knockout ( eNOS-KO mice) and wild-type ( WT) control mice. Interestingly, the LE- ESW-induced acceleration of wound closure and the increase in VEGF expression and neovascularization was significantly attenuated in eNOS-KO mice compared with WT mice. Considered collectively, these results showed that eNOS was induced at the wound tissues by LE- ESW treatment and played a critical role in the therapeutic effects of this treatment by accelerating the wound healing by promoting VEGF expression and neovascularization. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|