Pharmacokinetics and pharmacodynamics of single-dose oral tolvaptan in fasted and non-fasted states in healthy Caucasian and Japanese male subjects.

Purpose: To compare the pharmacokinetics and pharmacodynamics of tolvaptan in Caucasian and Japanese healthy male subjects under fasting and non-fasting conditions. Methods: This was a single-center, parallel-group, randomized, open-label, three-period crossover trial of single oral doses of tolvapt...

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Publicado en:European Journal of Clinical Pharmacology Vol. 68; no. 12; pp. 1595 - 1604
Autores principales: Shoaf, Susan, Kim, Seong, Bricmont, Patricia, Mallikaarjun, Suresh
Formato: research tables/charts Journal Article
Publicado: Springer Nature Dec2012
Acceso en línea:Ver este registro en EBSCOhost