Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study.
Objective: To validate a newly developed quantification method that automatically detects and quantifies the joint space width (JSW) in hand radiographs. Repeatability, accuracy and sensitivity to changes in JSW were determined. The influence of joint location and joint shape on the measurements was...
| Published in: | Skeletal Radiology Vol. 41; no. 1; pp. 41 - 50 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jan2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104439609&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104439609 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Jan2012 vid: 41 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104439609 NLM21311883 2011750211 10.1007/s00256-011-1110-x NLM21311883 PMC3223586 104439609 ppf: 41 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study. aug: au: Huétink K van 't Klooster R Kaptein BL Watt I Kloppenburg M Nelissen RG Reiber JH Stoel BC Huétink, Kasper van 't Klooster, Ronald Kaptein, Bart L Watt, Iain Kloppenburg, Margreet Nelissen, Rob G H H Reiber, Johan H C Stoel, Berend C affil: Department of Radiology, Leiden University Medical Center, 9600, 2300, RC Leiden, The Netherlands sug: subj: Algorithms Hand Radiography Osteoarthritis Radiography Information Science Methods Radiographic Image Interpretation, Computer-Assisted Methods Cadaver Human Phantoms, Imaging Radiographic Image Enhancement Methods Reproducibility of Results Sensitivity and Specificity ab: Objective: To validate a newly developed quantification method that automatically detects and quantifies the joint space width (JSW) in hand radiographs. Repeatability, accuracy and sensitivity to changes in JSW were determined. The influence of joint location and joint shape on the measurements was tested.Methods: A mechanical micrometer set-up was developed to define and adjust the true JSW in an acrylic phantom joint and in human cadaver-derived phalangeal joints. Radiographic measurements of the JSW were compared to the true JSW. Repeatability, systematic error (accuracy) and sensitivity (defined as the smallest detectable difference (SDD)) were determined. The influence of joint position on the JSW measurement was assessed by varying the location of the acrylic phantom on the X-ray detector with respect to the X-ray beam and the influence of joint shape was determined by using morphologically different human cadaver joints.Results: The mean systematic error was 0.052 mm in the phantom joint and 0.210 mm in the cadaver experiment. In the phantom experiments, the repeatability was high (SDD = 0.028 mm), but differed slightly between joint locations (p = 0.046), and a change in JSW of 0.037 mm could be detected. Dependent of the joint shape in the cadaver hand, a change in JSW between 0.018 and 0.047 mm could be detected.Conclusions: The automatic quantification method is sensitive to small changes in JSW. Considering the published data of JSW decline in the normal and osteoarthritic population, the first signs of OA progression with this method can be detected within 1 or 2 years. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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