Why mammography screening has not lived up to expectations from the randomised trials.
We analysed the relation between tumour sizes and stages and the reported effects on breast cancer mortality with and without screening in trials and observational studies. The average tumour sizes in all the trials suggest only a 12% reduction in breast cancer mortality, which agrees with the 10% r...
| Publicado en: | Cancer Causes & Control Vol. 23; no. 1; pp. 15 - 22 |
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| Autores principales: | , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Jan2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104439638&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104439638 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Jan2012 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104439638 67683831 NLM22072221 2011750242 10.1007/s10552-011-9867-8 NLM22072221 104439638 ppf: 15 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Why mammography screening has not lived up to expectations from the randomised trials. aug: au: Gøtzsche PC Jørgensen KJ Zahl PH Mæhlen J Gøtzsche, Peter C Jørgensen, Karsten Juhl Zahl, Per-Henrik Mæhlen, Jan affil: Dept 3343, The Nordic Cochrane Centre, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark sug: subj: Breast Neoplasms Prevention and Control Breast Neoplasms Radiography Mammography Methods Breast Neoplasms Diagnosis Breast Neoplasms Pathology Clinical Trials Early Detection of Cancer Methods Female Health Screening Incidence Neoplasm Staging Female ab: We analysed the relation between tumour sizes and stages and the reported effects on breast cancer mortality with and without screening in trials and observational studies. The average tumour sizes in all the trials suggest only a 12% reduction in breast cancer mortality, which agrees with the 10% reported in the most reliable trials. Recent studies of tumour sizes and tumour stages show that screening has not lowered the rate of advanced cancers. In agreement with this, recent observational studies of breast cancer mortality have failed to find an effect of screening. In contrast, screening leads to serious harms in healthy women through overdiagnosis with subsequent overtreatment and false-positive mammograms. We suggest that the rationale for breast screening be urgently reassessed by policy-makers. The observed decline in breast cancer mortality in many countries seems to be caused by improved adjuvant therapy and breast cancer awareness, not screening. We also believe it is more important to reduce the incidence of cancer than to detect it 'early.' Avoiding getting screening mammograms reduces the risk of becoming a breast cancer patient by one-third. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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