Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE).
Purpose: This study explored interactions between prenatal exposure to maternal smoking and polymorphisms in metabolic genes in the risk of childhood acute leukemia (AL). Methods: The data were generated by the ESCALE study, which included 764 AL cases and 1,681 controls in 2003-2004. The data on ma...
| Publicado en: | Cancer Causes & Control Vol. 23; no. 2; pp. 329 - 346 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104439994&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104439994 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Feb2012 vid: 23 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104439994 NLM22200898 2011750721 10.1007/s10552-011-9882-9 NLM22200898 104439994 ppf: 329 ppct: 17 formats: fmt: @attributes: type: P tig: atl: Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). aug: au: Bonaventure A Goujon-Bellec S Rudant J Orsi L Leverger G Baruchel A Bertrand Y Nelken B Pasquet M Michel G Sirvent N Bordigoni P Ducassou S Rialland X Zelenika D Hémon D Clavel J Bonaventure, Audrey Goujon-Bellec, Stéphanie Rudant, Jérémie affil: Inserm, UMRS 1018, CESP, Team 6 Environmental Epidemiology of Cancer, Villejuif, France sug: subj: Leukemia, Myeloid, Acute Prenatal Exposure Delayed Effects Smoking Adolescence Alleles Hydrocarbons, Aromatic Metabolism Case Control Studies Child Child, Preschool Oxidoreductases Hemeproteins Hydrolases Europe Genes Female Phenotype Disease Susceptibility Sequence Analysis Methods Genotype Human Leukemia, Myeloid, Acute Metabolism Logistic Regression Male Polymorphism, Genetic Pregnancy Pregnancy Complications, Neoplastic Pregnancy Complications, Neoplastic Metabolism Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Purpose: This study explored interactions between prenatal exposure to maternal smoking and polymorphisms in metabolic genes in the risk of childhood acute leukemia (AL). Methods: The data were generated by the ESCALE study, which included 764 AL cases and 1,681 controls in 2003-2004. The data on maternal smoking during pregnancy were obtained by standardized telephone interview of the cases' and controls' mothers. The genotypes CYP1A1*2A/2B (rs4646903), CYP2E1*5 (rs2031920, rs3813867), NQO1*2 (rs1800566), NAT2*5 (rs1801280), and EPHX1 exon 3 (rs1051740) and exon 4 (rs2234922) were obtained using a high-throughput platform and imputation for untyped polymorphisms. The analyses were restricted to the 493 cases (433 cases of lymphoblastic (ALL) and 51 of myeloblastic (AML) leukemia) and 441 controls with at least 2 grandparents born in Europe, who were genotyped with individual call rates greater than 95%. Odds ratios were estimated by logistic regression in case-control analyses and, for gene-gene and gene-environment interactions, by case-only analyses. Results: ALL and AML were not associated with either maternal smoking during pregnancy or candidate polymorphisms in CYP1A1, CYP2E1, EPHX1, and NQO1. Carrying two NAT2*5 alleles was significantly associated with ALL (OR = 1.8 [1.3-2.5]). The analyses also suggested an interaction between three genes involved in benzene metabolism CYP2E1, NQO1, and EPHX1. There was no interaction between maternal smoking and any of the polymorphisms under study. Conclusions: The ESCALE study did not evidence the interaction between CYP1A1*2A/2B and maternal smoking suggested previously. The association with NAT2*5 and the gene-gene interactions need to be replicated. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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