Lower leg muscle involvement in Duchenne muscular dystrophy: an MR imaging and spectroscopy study.
Objective: To describe the involvement of lower leg muscles in boys with Duchenne muscular dystrophy (DMD) by using MR imaging (MRI) and spectroscopy (MRS) correlated to indices of functional status.Subjects and Methods: Nine boys with DMD (mean age, 11 years) and eight healthy age- and BMI-matched...
| Publicado en: | Skeletal Radiology Vol. 41; no. 4; pp. 437 - 446 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104440427&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104440427 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Apr2012 vid: 41 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104440427 NLM21800026 2011751186 10.1007/s00256-011-1240-1 NLM21800026 PMC3713639 104440427 ppf: 437 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Lower leg muscle involvement in Duchenne muscular dystrophy: an MR imaging and spectroscopy study. aug: au: Torriani M Townsend E Thomas BJ Bredella MA Ghomi RH Tseng BS Torriani, Martin Townsend, Elise Thomas, Bijoy J Bredella, Miriam A Ghomi, Reza H Tseng, Brian S affil: Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA sug: subj: Leg Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Muscle, Skeletal Physiopathology Muscular Dystrophy, Duchenne Diagnosis Adolescence Child Human Male Muscular Dystrophy, Duchenne Physiopathology Prospective Studies Adolescent: 13-18 years Child: 6-12 years Male ab: Objective: To describe the involvement of lower leg muscles in boys with Duchenne muscular dystrophy (DMD) by using MR imaging (MRI) and spectroscopy (MRS) correlated to indices of functional status.Subjects and Methods: Nine boys with DMD (mean age, 11 years) and eight healthy age- and BMI-matched boys (mean age, 13 years) prospectively underwent lower leg MRI, 1H-MRS of tibialis anterior (TA) and soleus (SOL) for lipid fraction measures, and 31P-MRS for pH and high-energy phosphate measures. DMD subjects were evaluated using the Vignos lower extremity functional rating, and tests including 6 min walk test (6MWT) and 10 m walk.Results: DMD subjects had highest fatty infiltration scores in peroneal muscles, followed by medial gastrocnemius and soleus. Compared to controls, DMD boys showed higher intramuscular fat (P = 0.04), lipid fractions of TA and SOL (P = 0.02 and 0.003, respectively), pH of anterior compartment (P = 0.0003), and lower phosphocreatine/inorganic phosphorus ratio of posterior compartment (P = 0.02). The Vignos rating correlated with TA (r = 0.79, P = 0.01) and SOL (r = 0.71, P = 0.03) lipid fractions. The 6MWT correlated with fatty infiltration scores of SOL (r = -0.76, P = 0.046), medial (r = -0.80, P = 0.03) and lateral (r = -0.84, P = 0.02) gastrocnemius, intramuscular fat (r = -0.80, P = 0.03), and SOL lipid fraction (r = -0.89, P = 0.007). Time to walk 10 m correlated with anterior compartment pH (r = 0.78, P = 0.04).Conclusion: Lower leg muscles of boys with DMD show a distinct involvement pattern and increased adiposity that correlates with functional status. Lower leg MRI and 1H-MRS studies may help to noninvasively demonstrate the severity of muscle involvement. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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