Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET.

Purpose: (R)-[(11)C]rolipram and (S)-[(11)C]rolipram have been proposed to investigate phosphodiesterase-4 and, indirectly, cAMP-mediated signaling with PET. This study assessed binding of these tracers to phosphodiesterase-4 in canine myocardium.Procedures: Seven dogs underwent (R)-[(11)C]rolipram...

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Publicado en:	Molecular Imaging & Biology Vol. 14; no. 2; pp. 225 - 237
Autores principales:	Lortie M, DaSilva JN, Kenk M, Thorn S, Davis D, Birnie D, Beanlands RS, deKemp RA, Lortie, Mireille, DaSilva, Jean N, Kenk, Miran, Thorn, Stephanie, Davis, Darryl, Birnie, David, Beanlands, Rob S B, deKemp, Robert A
Formato:	research Journal Article
Publicado:	Springer Nature Apr2012
Acceso en línea:	Ver este registro en EBSCOhost