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Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer.

Purpose: To investigate the utility of (11)C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment after neoadjuvant chemotherapy.Procedures: Seventeen patients underwent (11)C-acetate PET/CT ≤1 month before radical cystectomy (RC) an...

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Published in:Molecular Imaging & Biology Vol. 14; no. 2; pp. 245 - 252
Main Authors: Schöder H, Ong SC, Reuter VE, Cai S, Burnazi E, Dalbagni G, Larson SM, Bochner BH, Schöder, Heiko, Ong, Seng C, Reuter, Victor E, Cai, Shangde, Burnazi, Eva, Dalbagni, Guido, Larson, Steven M, Bochner, Bernard H
Format: Journal Article
Published: Springer Nature Apr2012
Online Access:View this record in EBSCOhost
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      jtl: Molecular Imaging & Biology
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      dt: Apr2012
      vid: 14
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      pub: Springer Nature
      place: New York, New York
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        NLM21491174
        2011751388
        10.1007/s11307-011-0488-0
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        atl: Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer.
      aug:
        au:
          Schöder H
          Ong SC
          Reuter VE
          Cai S
          Burnazi E
          Dalbagni G
          Larson SM
          Bochner BH
          Schöder, Heiko
          Ong, Seng C
          Reuter, Victor E
          Cai, Shangde
          Burnazi, Eva
          Dalbagni, Guido
          Larson, Steven M
          Bochner, Bernard H
        affil: Department of Radiology, Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
      sug:
        subj:
          Acetic Acid Diagnostic Use
          Bladder Neoplasms
          Bladder Neoplasms Pathology
          Adult
          Aged
          Radioisotopes
          Female
          Lymph Nodes Radiography
          Male
          Middle Age
          Mycobacterium
          Neoplasm Staging
          Bladder Neoplasms Microbiology
          Bladder Neoplasms Radiography
          Adult: 19-44 years
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Purpose: To investigate the utility of (11)C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment after neoadjuvant chemotherapy.Procedures: Seventeen patients underwent (11)C-acetate PET/CT ≤1 month before radical cystectomy (RC) and pelvic lymph node dissection (PLND). Ten patients had undergone neoadjuvant chemotherapy prior to PET. Histopathology from RC and PLND (n = 16) or nodal biopsy (n = 1) served as gold standard.Results: Eight of 10 residual tumors showed abnormal (11)C-acetate uptake; two cases of residual TiS were false negative, three cases were false positive, and three true negative. Three patients showed true positive uptake in LN. False positive uptake occurred in 14 LN regions secondary to granulomatous disease after prior intravesical Bacillus Calmette-Guerin (BCG) therapy.Conclusions: (11)C-acetate has good sensitivity for bladder cancer and LN metastases. However, false positive uptake due to inflammation or granulomatous infection can occur, limiting the staging utility of (11)C-acetate after prior intravesical BCG therapy.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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