Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping.
Purpose: Radioscintigraphic imaging during sentinel lymph node (SLN) mapping could potentially improve localization; however, parallel-hole collimators have certain limitations. In this study, we explored the use of coded aperture (CA) collimators.Procedures: Equations were derived for the six major...
| Publicado en: | Molecular Imaging & Biology Vol. 14; no. 2; pp. 173 - 183 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104442882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104442882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Apr2012 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104442882 NLM21567254 2011751393 10.1007/s11307-011-0494-2 NLM21567254 PMC3156935 104442882 ppf: 173 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping. aug: au: Fujii H Idoine JD Gioux S Accorsi R Slochower DR Lanza RC Frangioni JV Fujii, Hirofumi Idoine, John D Gioux, Sylvain Accorsi, Roberto Slochower, David R Lanza, Richard C Frangioni, John V affil: Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA sug: subj: Lymph Nodes Pathology Lymph Nodes Radiography Radionuclide Imaging Equipment and Supplies Sentinel Lymph Node Biopsy Equipment and Supplies Animal Studies Human Light Mice Reproducibility of Results Spectroscopy, Near-Infrared Swine ab: Purpose: Radioscintigraphic imaging during sentinel lymph node (SLN) mapping could potentially improve localization; however, parallel-hole collimators have certain limitations. In this study, we explored the use of coded aperture (CA) collimators.Procedures: Equations were derived for the six major dependent variables of CA collimators (i.e., masks) as a function of the ten major independent variables, and an optimized mask was fabricated. After validation, dual-modality CA and near-infrared (NIR) fluorescence SLN mapping were performed in pigs.Results: Mask optimization required the judicious balance of competing dependent variables, resulting in sensitivity of 0.35%, XY resolution of 2.0 mm, and Z resolution of 4.2 mm at an 11.5-cm field of view. The findings in pigs suggested that NIR fluorescence imaging and CA radioscintigraphy could be complementary, but present difficult technical challenges.Conclusions: This study lays the foundation for using CA collimation for SLN mapping, and also exposes several problems that require further investigation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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