Predictors of 25-hydroxyvitamin D and its association with risk factors for prostate cancer: evidence from the prostate testing for cancer and treatment study.
Purpose: Circulating 25-hydroxyvitamin D (25(OH)D) may protect against prostate and other cancers. Few epidemiology studies have measured 25(OH)D on all participants, weakening the evidence-base through reduced statistical power and the potential for bias. We developed a score to predict individual...
| Published in: | Cancer Causes & Control Vol. 23; no. 4; pp. 575 - 589 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Apr2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104443109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104443109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Apr2012 vid: 23 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104443109 NLM22382867 2011751701 10.1007/s10552-012-9919-8 NLM22382867 104443109 ppf: 575 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Predictors of 25-hydroxyvitamin D and its association with risk factors for prostate cancer: evidence from the prostate testing for cancer and treatment study. aug: au: Gilbert R Martin RM Fraser WD Lewis S Donovan J Hamdy F Neal DE Lane JA Metcalfe C Gilbert, Rebecca Martin, Richard M Fraser, William D Lewis, Sarah Donovan, Jenny Hamdy, Freddie Neal, David E Lane, J Athene Metcalfe, Chris affil: School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK sug: subj: Models, Statistical Prostatic Neoplasms Vitamin D Aged Diet Epidemiological Research Human Male Middle Age Risk Factors Sunlight Aged: 65+ years Middle Aged: 45-64 years Male ab: Purpose: Circulating 25-hydroxyvitamin D (25(OH)D) may protect against prostate and other cancers. Few epidemiology studies have measured 25(OH)D on all participants, weakening the evidence-base through reduced statistical power and the potential for bias. We developed a score to predict individual 25(OH)D based on potential predictors, including sun exposure, nutrient intake, and vitamin D pathway genes, providing a method of substituting missing values. We assessed the usefulness of predicted 25(OH)D by comparison with multiple imputation of 25(OH)D levels.Methods: Amongst 1,091 controls from a population-based case-control study (ProtecT), we quantified relationships of sun exposure, demographic, clinical, anthropologic, nutrient, and genetic data with circulating 25(OH)D and constructed several prediction scores from subsets of these measures. We investigated associations of three prostate cancer risk factors (PSA level, BMI, family history of prostate cancer) with 25(OH)D levels in sensitivity analyses based upon participants with measured 25(OH)D only and based upon the addition of all participants with missing 25(OH)D levels substituted by prediction score values or by multiple imputation.Results: Our score accounted for 27.7% of the variation in measured 25(OH)D. Associations with risk factors of prostate cancer were consistent across the different estimates of 25(OH)D. However, standard deviations for the prediction score did not incorporate extra error from prediction. Multiple imputation of missing 25(OH)D values predicted a more realistic range of 25(OH)D.Conclusion: In epidemiological studies of cancer risk associated with vitamin D, multiple imputation of missing 25(OH)D is preferable to prediction scores, as a wider range of 25(OH)D levels are imputed and appropriate confidence intervals calculated. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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