Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts.

Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polya...

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Publicado en:	Journal of Clinical Investigation Vol. 122; no. 5; pp. 1653 - 1667
Autores principales:	Moiani A, Paleari Y, Sartori D, Mezzadra R, Miccio A, Cattoglio C, Cocchiarella F, Lidonnici MR, Ferrari G, Mavilio F, Moiani, Arianna, Paleari, Ylenia, Sartori, Daniela, Mezzadra, Riccardo, Miccio, Annarita, Cattoglio, Claudia, Cocchiarella, Fabienne, Lidonnici, Maria Rosa, Ferrari, Giuliana, Mavilio, Fulvio
Formato:	research Journal Article
Publicado:	American Society for Clinical Investigation May2012
Acceso en línea:	Ver este registro en EBSCOhost