Uncovering the role of genomic "dark matter" in human disease.
The human genome encodes thousands of long noncoding RNAs (lncRNAs). Although most remain functionally uncharacterized biological "dark matter," lncRNAs have garnered considerable attention for their diverse roles in human biology, including developmental programs and tumor suppressor gene networks....
| Publicado en: | Journal of Clinical Investigation Vol. 122; no. 5; pp. 1589 - 1596 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
American Society for Clinical Investigation
May2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104443541&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104443541 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00219738 0YX jtl: Journal of Clinical Investigation issn: 00219738 maglogo: N pubinfo: dt: May2012 vid: 122 iid: 5 pid: 11983 pub: American Society for Clinical Investigation place: Ann Arbor, Michigan artinfo: ui: 104443541 NLM22546862 2011752202 10.1172/JCI60020 NLM22546862 PMC3336981 104443541 ppf: 1589 ppct: 7 formats: tig: atl: Uncovering the role of genomic "dark matter" in human disease. aug: au: Martin L Chang HY Martin, Lance Chang, Howard Y affil: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA sug: subj: Genes Genome, Human RNA Physiology Cell Cycle Neoplasms Neoplasms Metabolism RNA RNA Metabolism Funding Source Human ab: The human genome encodes thousands of long noncoding RNAs (lncRNAs). Although most remain functionally uncharacterized biological "dark matter," lncRNAs have garnered considerable attention for their diverse roles in human biology, including developmental programs and tumor suppressor gene networks. As the number of lncRNAs associated with human disease grows, ongoing research efforts are focusing on their regulatory mechanisms. New technologies that enable enumeration of lncRNA interaction partners and determination of lncRNA structure are well positioned to drive deeper understanding of their functions and involvement in pathogenesis. In turn, lncRNAs may become targets for therapeutic intervention or new tools for biotechnology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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