Microvessel density but not neoangiogenesis is associated with 18F-FDG uptake in human atherosclerotic carotid plaques.
Introduction: The vulnerable atherosclerotic lesion exhibits the proliferation of neovessels and inflammation. The imaging modality 2-deoxy-2-[(18)F]fluoro-D: -glucose positron emission tomography ((18)FDG-PET) is considered for the identification of vulnerable plaques.Purpose: The purpose of this s...
| Published in: | Molecular Imaging & Biology Vol. 14; no. 3; pp. 384 - 393 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jun2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104443617&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104443617 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2012 vid: 14 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104443617 104443617 NLM21732164 2011752279 10.1007/s11307-011-0507-1 NLM21732164 104443617 ppf: 384 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Microvessel density but not neoangiogenesis is associated with 18F-FDG uptake in human atherosclerotic carotid plaques. aug: au: Pedersen SF Graebe M Hag AM Hoejgaard L Sillesen H Kjaer A Pedersen, Sune Folke Graebe, Martin Hag, Anne Mette Fisker Hoejgaard, Liselotte Sillesen, Henrik Kjaer, Andreas affil: Cluster for Molecular Imaging, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark sug: subj: Carotid Stenosis Metabolism Fludeoxyglucose F 18 Pharmacokinetics Blood Vessels Metabolism Neovascularization, Pathologic Metabolism Atherosclerosis Metabolism Aged Aged, 80 and Over Antigens, Surface Antigens, Surface Metabolism Carotid Stenosis Radiography Female Gene Expression Profiling Human Receptors, Cell Surface Receptors, Cell Surface Metabolism Linear Regression Male Blood Vessels Radiography Middle Age Neovascularization, Pathologic Radiography Atherosclerosis Radiography Tomography, Emission-Computed Endothelial Growth Factors Endothelial Growth Factors Metabolism Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Introduction: The vulnerable atherosclerotic lesion exhibits the proliferation of neovessels and inflammation. The imaging modality 2-deoxy-2-[(18)F]fluoro-D: -glucose positron emission tomography ((18)FDG-PET) is considered for the identification of vulnerable plaques.Purpose: The purpose of this study was to compare the gene expression of neoangiogenesis and vulnerability-associated genes with (18)FDG uptake in patients undergoing carotid endarterectomy.Procedures: Human atherosclerotic carotid artery plaques from symptomatic patients were used for gene expression analysis by quantitative PCR of vascular endothelial growth factor (VEGF) and integrin α(V) and integrin β(3) subunits, genes essential during neoangiogenesis. We also evaluated the gene expression of CD34, a measure of microvessel density (MVD), as well as CD68, MMP-9, and cathepsin K, genes of major importance in plaque vulnerability. Gene expression analysis was compared with (18)FDG-PET.Results: VEGF and integrin α(V)β(3) gene expression did not correlate with (18)FDG uptake, whereas CD34 gene expression exhibited an inverse correlation with (18)FDG uptake. Additionally, we established that markers of vulnerability were correlated with (18)FDG uptake.Conclusions: Neoangiogenesis is not associated with (18)FDG uptake, whereas MVD and markers of vulnerability correlate with (18)FDG uptake. The absence of correlation between markers of neoangiogenesis and (18)FDG uptake suggests a temporal separation between the process of neoangiogenesis and inflammatory activity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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