Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects--data from the Osteoarthritis Initiative.
Objective: To study the effect of BMI on the prevalence, severity, and 36-month progression of early degenerative changes in the knee by using 3T MRI in middle-aged subjects without radiographic osteoarthritis (OA).Materials and Methods: We examined baseline and 36-month follow-up MR studies from 13...
| Publicado en: | Skeletal Radiology Vol. 41; no. 6; pp. 633 - 642 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104443694&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104443694 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Jun2012 vid: 41 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104443694 104443694 NLM21887596 2011752359 10.1007/s00256-011-1259-3 NLM21887596 PMC4105189 104443694 ppf: 633 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects--data from the Osteoarthritis Initiative. aug: au: Laberge MA Baum T Virayavanich W Nardo L Nevitt MC Lynch J McCulloch CE Link TM Laberge, Marc A Baum, Thomas Virayavanich, Warapat Nardo, Lorenzo Nevitt, M C Lynch, J McCulloch, C E Link, Thomas M affil: Musculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA sug: subj: Body Mass Index Magnetic Resonance Imaging Statistics and Numerical Data Obesity Diagnosis Obesity Epidemiology Osteoarthritis, Knee Diagnosis Osteoarthritis, Knee Epidemiology Comorbidity Female Human Male Middle Age Prevalence Reproducibility of Results Risk Assessment Risk Factors California Sensitivity and Specificity Middle Aged: 45-64 years Female Male ab: Objective: To study the effect of BMI on the prevalence, severity, and 36-month progression of early degenerative changes in the knee by using 3T MRI in middle-aged subjects without radiographic osteoarthritis (OA).Materials and Methods: We examined baseline and 36-month follow-up MR studies from 137 middle-aged individuals (45-55 years old) with risk factors for knee OA but no radiographic OA from the Osteoarthritis Initiative. Subjects were grouped into three categories: normal BMI (BMI < 25 kg/m(2), n = 38), overweight (BMI 25-29.9 kg/m(2), n = 37), and obese (BMI ≥ 30 kg/m(2), n = 62). Using 3T MRI, cartilage, meniscus, and bone marrow abnormalities were graded using the OA Whole-organ MR Imaging Score (WORMS). The statistical analysis was corrected as necessary for differences in age, sex, and OA risk factors other than BMI.Results: The overall prevalence of lesions was 64% for meniscus and 79% for cartilage (including low grade lesions). At baseline, the prevalence and severity of knee lesions was positively associated with BMI, with a nearly fourfold increase in meniscal tears and more than twofold increase in high-grade cartilage defects in obese individuals relative to normal-weight subjects. Over the 36-month follow-up period, the number of new or worsening cartilage lesions of any grade was significantly higher in obese subjects (p = 0.039), while there was no significant difference in meniscal lesion progression.Conclusion: Obesity was associated with both higher prevalence and severity of early degenerative changes in the knee in middle-aged individuals without radiographic OA and with significantly increased cartilage lesion progression (of any grade) over 36 months. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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