ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer.
Castration-resistant prostate cancer is the second most common cause of cancer death and results in a median survival of less than 2 years. In prostate cancer, fusions between TMPRSS2 and ERG are common. The ERG rearrangement prevalence in local recurrent castration-resistant prostate cancer compare...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 461; no. 2; pp. 157 - 163 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104444643&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104444643 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Aug2012 vid: 461 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104444643 NLM22767266 2011753822 10.1007/s00428-012-1270-7 NLM22767266 104444643 ppf: 157 ppct: 6 formats: fmt: @attributes: type: P tig: atl: ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer. aug: au: Scheble VJ Scharf G Braun M Ruiz C Stürm S Petersen K Beschorner R Bachmann A Zellweger T Fend F Kristiansen G Bubendorf L Wernert N Shaikhibrahim Z Perner S Scheble, Veit J Scharf, Gregor Braun, Martin Ruiz, Christian Stürm, Susanna affil: Institute of Pathology, University Hospital Tuebingen, Tuebingen, Germany sug: subj: Drug Resistance, Neoplasm Genes Prostatic Neoplasms Prostatic Neoplasms Pathology Proteins Antineoplastic Agents, Hormonal Therapeutic Use Surgery, Urogenital Methods Gene Amplification In Situ Hybridization, Fluorescence Male Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Recurrence, Local Pathology Prostatic Neoplasms Drug Therapy Receptors, Cell Surface Tissue Array Analysis Male ab: Castration-resistant prostate cancer is the second most common cause of cancer death and results in a median survival of less than 2 years. In prostate cancer, fusions between TMPRSS2 and ERG are common. The ERG rearrangement prevalence in local recurrent castration-resistant prostate cancer compared to distant metastatic prostate cancer is unknown. We investigated the frequency of ERG rearrangement in local recurrent castration-resistant prostate cancer compared to distant metastatic prostate cancer, and assessed for associations between androgen receptor (AR) amplification and ERG rearrangement status. Samples from 134 patients diagnosed with prostate cancer (84 local recurrent castration resistant prostate cancer, 55 distant metastatic prostate cancer) were assessed for their ERG rearrangement and AR amplification status by fluorescence in situ hybridization. Statistical analysis was performed using the χ (2) test. We found that the ERG rearrangement occurs at a significantly lower frequency in distant metastatic prostate cancer (25 %) than in local recurrent castration-resistant prostate cancer (45 %). The AR amplification frequencies were 45 and 35 % in local recurrent castration-resistant prostate cancer and distant metastatic prostate cancer, respectively. The ERG rearrangement occurred at a lower frequency in distant metastatic prostate cancer compared to local recurrent castration-resistant prostate cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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