Prenatal Lead Levels, Plasma Amyloid β Levels, and Gene Expression in Young Adulthood.
Background: Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimerfs disease (AD). Objectives: We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and wo...
| Publicado en: | Environmental Health Perspectives Vol. 120; no. 5; pp. 702 - 708 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
May2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104445882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104445882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: May2012 vid: 120 iid: 5 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104445882 75166953 10.1289/ehp.1104474 104445882 ppf: 702 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Prenatal Lead Levels, Plasma Amyloid β Levels, and Gene Expression in Young Adulthood. aug: au: Mazumdar, Maitreyi Xia, Weiming Hofmann, Oliver Gregas, Matthew Sui, Shannan Ho Hide, Winston Yang, Ting Needleman, Herbert L. Bellinger, David C. affil: Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, USA; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA sug: subj: Gene Expression In Adulthood Lead Adverse Effects Environmental Exposure Adverse Effects Biological Markers Alzheimer's Disease Familial and Genetic Proteins Blood Prospective Studies Fetal Blood Analysis Exploratory Research Fetus Fetal Development Infant, Newborn Infant Child Child, Preschool Human Male Female Lead Blood Spectrum Analysis Questionnaires Enzyme-Linked Immunosorbent Assay RNA Blood Linear Regression Databases Descriptive Statistics Adult Funding Source Fetus, conception to birth Infant, Newborn: birth-1 month Infant: 1-23 months Child: 6-12 years Child, Preschool: 2-5 years Adult: 19-44 years Male Female ab: Background: Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimerfs disease (AD). Objectives: We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempted to assess whether early-life lead exposure was associated with changes in expression of AD-related genes. Methods: We used sandwich enzyme-linked immunosorbent assays (ELISA) to measure plasma concentrations of amyloid β proteins Aβ40 and Aβ42 among 55 adults who had participated as newborns and young children in a prospective cohort study of the effects of lead exposure on development. We used RNA microarray techniques to analyze gene expression. Results: Mean plasma Aβ42 concentrations were lower among 13 participants with high umbilical cord blood lead concentrations (≥ 10 µg/dL) than in 42 participants with lower cord blood lead concentrations (p = 0.08). Among 10 participants with high prenatal lead exposure, we found evidence of an inverse relationship between umbilical cord lead concentration and expression of ADAM metallopeptidase domain 9 (ADAM9), reticulon 4 (RTN4), and low-density lipoprotein receptor-related protein associated protein 1 (LRPAP1) genes, whose products are believed to affect Aβ production and deposition. Gene network analysis suggested enrichment in gene sets involved in nerve growth and general cell development. Conclusions: Data from our exploratory study suggest that prenatal lead exposure may influence Aβ-related biological pathways that have been implicated in AD onset. Gene network analysis identified further candidates to study the mechanisms of developmental lead neurotoxicity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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