Metallobeta-lactamase enzymes and antibiotic susceptibilities in strains of pseudomonas aeruginosa isolated from intensive care units in Turkey.
Objective: The aim of this study was to determine the frequency of metallobeta-lactamase (MBL) enzyme in Pseudomonas aeruginosa strains resistant to carbapenem (imipenem or/and meropenem) in seven regions of Turkey and to assess the minimal inhibitory concentration (MIC) levels of drugs used in trea...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 3; pp. 687 - 694 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104446191&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104446191 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Jun2012 vid: 32 iid: 3 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104446191 2011551568 10.5336/medsci.2011-24972 104446191 ppf: 687 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Metallobeta-lactamase enzymes and antibiotic susceptibilities in strains of pseudomonas aeruginosa isolated from intensive care units in Turkey. aug: au: Cesur, Salih Yildiz, Eda Irmak, Hasan Gülay, Zeynep Arslan, Ugur Nevgun, Sepin Özen Bayramoglu, Gülçin Berktas, Mustafa Gencer, Serap Hosoglu, Salih Demiröz, Ali Pekcan sug: subj: Drug Resistance, Microbial Intensive Care Units Microbial Culture and Sensitivity Tests Pseudomonas Infections Complications Antibiotics Adverse Effects Human In Vitro Studies Turkiye ab: Objective: The aim of this study was to determine the frequency of metallobeta-lactamase (MBL) enzyme in Pseudomonas aeruginosa strains resistant to carbapenem (imipenem or/and meropenem) in seven regions of Turkey and to assess the minimal inhibitory concentration (MIC) levels of drugs used in treatment such as colistin, aztreonam, polymyxin B and rifampin. Overall 186 Pseudomonas aeruginosa (P.aeruginosa) strains resistant to carbapenem from 8 provinces (Ankara, Konya, Antalya, I.stanbul, I.zmir, Diyarbak?r, Van and Trabzon) representing 7 different geographical regions of Turkey were included in the study. Material and Methods: The presence of MBL in P.aeruginosa strains resistant to carbapenem was investigated by combined disk methods with imipenem and EDTA absorbed imipenem disk. The MBL positivity was determined in the strains. Additionally, susceptibility to aztreonam, colistin, polymyxin B, and rifampin was established by the E-test method. Results: MBL enzyme positivity was detected in 58 out of 186 strains (31.2%). There was statistically significant difference between regions in terms of MBL positivity, with the highest rates in Antalya (52%), and I.stanbul (50%) and the lowest in Diyarbak?r (6%). Aztreonam sensitivity was detected in 134 (72 %) strains; 155 (83.3%) were sensitive to colistin and 148 (79.6%) to polymixine. No strain (0%) was sensitive to rifampin. Conclusion: In conclusion, the overall mean rate of MBL positivity was 31.2%, which is quite high. Therefore, it will be beneficial to confirm the MBL positivity of strains with molecular methods, to review regional antibiotic surveillance data at certain intervals and to share the obtained data with relevant institutions in order to prevent the regional spread of these strains. Thus, it is essential to record and monitor systematically the antibiotic surveillance data. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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