Poretective effect of melatonin on the oxidative stress caused by diabetes and forced swimming exercise on rat brain tissue.
Objective: The objective of the present study is to examine how melatonin supplementation affects lipid peroxidation in the brain tissue of diabetic rats subjected to acute swimming exercise. Material and Methods: The study was carried out on 80 Spraque-Dawley type adult male rats, which were equall...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 3; pp. 782 - 788 |
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| Autor principal: | |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104446218&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104446218 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Jun2012 vid: 32 iid: 3 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104446218 104446218 2011551597 10.5336/medsci.2011-27367 104446218 ppf: 782 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Poretective effect of melatonin on the oxidative stress caused by diabetes and forced swimming exercise on rat brain tissue. aug: au: Biçer, Mürsel sug: subj: Brain Physiology Diabetes Mellitus Complications Melatonin Oxidative Stress Swimming Animal Studies Coefficient alpha Data Analysis Software Kruskal-Wallis Test Malondialdehyde Analysis Mann-Whitney U Test Models, Biological Post Hoc Analysis Rats ab: Objective: The objective of the present study is to examine how melatonin supplementation affects lipid peroxidation in the brain tissue of diabetic rats subjected to acute swimming exercise. Material and Methods: The study was carried out on 80 Spraque-Dawley type adult male rats, which were equally allocated to 8 groups: Group 1, general control; Group 2, melatonin-supplemented control; Group 3, melatonin-supplemented diabetic control; Group 4, swimming control; Group 5, melatonin-supplemented swimming; Group 6, melatonin-supplemented diabetic swimming; Group 7, diabetic swimming; and Group 8, diabetic control. The animals were injected with 40 mg/kg subcutaneous streptozotocin (STZ). The same dose was repeated after 24 hours. The rats were supplemented with 3 mg/kg/day intraperitoneal (ip) melatonin for 4 weeks. Brain tissue samples were collected from the animals, which were decapitated at the end of the study, to determine malondialdehyde (MDA) (nmol/gram/protein) and glutathione (GSH) (mg/dL/gram protein) levels. Results: The highest MDA values in brain tissue were in Group 7 and 8. Groups 3 and 6 had the highest brain GSH values. Brain GSH values in Group 2 were lower than the values in Groups 3 and 6, but higher than those in all other groups. The lowest GSH values in brain tissue were established in Groups 7 and 8. Conclusion: Results of the present study indicate that the oxidative stress caused by diabetes and acute swimming exercise in rat brain tissue can be offset by melatonin supplementation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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