Experimental study on anti-inflammatory activity of a TCM recipe consisting of the supercritical fluid CO2 extract of Chrysanthemum indicum, Patchouli Oil and Zedoary Turmeric Oil in vivo.
Abstract: Ethnopharmacological relevance: Chrysanthemum indicum (Compositae) Linné, Pogostemon cablin (Blanco) Benth and Curcuma wenyujin (Zingiberaceae) Y. H. Chen et C. Ling are three of the extensively used herbal remedies among traditional Chinese medicines for the purpose of anti-inflammation....
| Publicado en: | Journal of Ethnopharmacology Vol. 141; no. 2; pp. 608 - 615 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104448085&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104448085 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03788741 3MS jtl: Journal of Ethnopharmacology issn: 03788741 maglogo: N pubinfo: dt: Jun2012 vid: 141 iid: 2 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104448085 75354474 10.1016/j.jep.2011.08.055 NLM21920423 104448085 ppf: 608 ppct: 7 formats: tig: atl: Experimental study on anti-inflammatory activity of a TCM recipe consisting of the supercritical fluid CO2 extract of Chrysanthemum indicum, Patchouli Oil and Zedoary Turmeric Oil in vivo. aug: au: Su, Ji-Yan Tan, Li-Rong Lai, Ping Liang, Hai-Chun Qin, Zhen Ye, Mu-Rong Lai, Xiao-Ping Su, Zi-Ren affil: Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, China sug: subj: Antiinflammatory Agents Pharmacodynamics Medicine, Chinese Traditional Medicine, Herbal Plants, Medicinal Pharmacodynamics Alternative Therapies In Vivo Studies Animal Studies Mice Rats Descriptive Statistics Prostaglandins Analysis Interleukins Analysis Tumor Necrosis Factor Analysis Nitric Oxide Analysis Enzyme-Linked Immunosorbent Assay ab: Abstract: Ethnopharmacological relevance: Chrysanthemum indicum (Compositae) Linné, Pogostemon cablin (Blanco) Benth and Curcuma wenyujin (Zingiberaceae) Y. H. Chen et C. Ling are three of the extensively used herbal remedies among traditional Chinese medicines for the purpose of anti-inflammation. A traditional Chinese medicine (TCM) recipe named CPZ consisting extracts of the above three herbs, has shown noteworthy anti-influenza activity, which is closely related to its anti-inflammatory feature. Aim of this study: To investigated the anti-inflammtory activity of CPZ in vivo for a further exploration of the recipe''s anti-inflammatory properties. Materials and methods: The anti-inflammatory property of CPZ on acute inflammation was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ear vasodilatation and acetic acid-induced capillary permeability enhancement in mice, as well as the carrageenan-induced paw edema rat model, in which inflammation-related cytokine including prostaglandin E2 (PGE2), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in the edematous paw tissue were determined by enzyme linked immunosorbent assay (ELISA). Moreover, effect of CPZ on chronic inflammation was observed through granuloma formation in rats subjected to cotton pellet implantation. Results: CPZ (340, 170, and 85mg/kg for mice, p.o.) not only decreased the DMB-induced ear vasodilatation but also attenuated capillary permeability under acetic acid challenge in mice. And the significant inhibition on carrageenan-induced paw edema was observed. Further more, the ELISA results showed that CPZ (170, 85, and 42.5mg/kg for rats, p.o.) could up-regulate the level of IL-1β in the edema paw tissue of rats significantly while down-regulate that of PGE2, but no apparent effect on TNF-α or NO was observed in the test. Besides, CPZ had a certain degree of restraining effect on the cotton pellet-induced granuloma formation in rats and the highest dose of 170mg/kg even showed a significant suppression on it. Conclusion: The above results indicated that CPZ possessed a potent anti-inflammatory activity, which is indicated to be closely associated with its regulation on IL-1β and PGE2 thereby mediating the inflammatory response acting at an appropriate level. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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