The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats.
Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 50; no. 6; pp. 585 - 594 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104451366&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104451366 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jun2012 vid: 50 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104451366 NLM22562369 2011562931 10.1007/s11517-012-0912-x NLM22562369 PMC3608097 104451366 ppf: 585 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats. aug: au: Yang M Murfee WL Yang, Ming Murfee, Walter L affil: Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA sug: subj: Blood Vessels Pathology Hypertension Pathology Vascular Resistance Physiology Animal Studies Hypertension Physiopathology Male Microcirculation Physiology Rats Splanchnic Circulation Physiology Male ab: Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15-16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascular network resistance was not elevated compared to the WKY level. Our results suggest that microvascular pattern alterations associated with hypertension are more complex than vessel loss, and that these combined alterations do not necessarily lead to elevated resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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