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Management of Transfusion-Related Iron Overload in Patients With Myelodysplastic Syndromes.

Anemia is a common symptom for patients with myelodysplastic syndromes (MDS), a spectrum of hematopoietic malignancies characterized by ineffective hematopoiesis; 90% of these patients will become transfusion dependent (TD). Because of the closed nature of iron metabolism, the repeated input of pack...

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Published in:Clinical Journal of Oncology Nursing Vol. 16; pp. 37 - 47
Main Authors: Shah, Jayshree, Kurtin, Sandra E., Arnold, Louise, Lindroos-Kolqvist, Petra, Tinsley, Sara
Format: pictorial tables/charts Journal Article
Published: Oncology Nursing Society Jun2012 Supplement
Online Access:View this record in EBSCOhost
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      dt: Jun2012 Supplement
      vid: 16
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      pub: Oncology Nursing Society
      place: Pittsburgh, Pennsylvania
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        atl: Management of Transfusion-Related Iron Overload in Patients With Myelodysplastic Syndromes.
      aug:
        au:
          Shah, Jayshree
          Kurtin, Sandra E.
          Arnold, Louise
          Lindroos-Kolqvist, Petra
          Tinsley, Sara
        affil: Leukemia Division of the John Theurer Cancer Center, Hackensack University Medical Center in New Jersey
      sug:
        subj:
          Myelodysplastic Syndromes
          Iron Overload Therapy
          Blood Component Transfusion Adverse Effects
          Anemia Therapy
          Iron Overload Physiopathology
          Iron Overload Diagnosis
          Iron Overload Drug Therapy
          Chelation Therapy Economics
          Deferoxamine Administration and Dosage
          Hematologic Tests
          Magnetic Resonance Imaging
          Phlebotomy
      ab: Anemia is a common symptom for patients with myelodysplastic syndromes (MDS), a spectrum of hematopoietic malignancies characterized by ineffective hematopoiesis; 90% of these patients will become transfusion dependent (TD). Because of the closed nature of iron metabolism, the repeated input of packed red blood cells during transfusions inevitably leads to iron overload. Iron overload can cause iron-related toxicity as well as end-organ damage from iron deposition in tissues. Studies have shown that patients with MDS who are TD have shorter overall survival, shorter leukemia-free survival, and higher healthcare costs compared with patients who are not TD, suggesting that iron overload has a significant clinical and economic impact. Iron chelation therapy can bind and eliminate free iron from the body. Although studies in genetic anemias have shown improved clinical outcomes, clinical trials with patients with MDS are ongoing. Because iron chelation therapy can be toxic, the risks, benefits, and therapy-related costs must be weighed for each patient.
      pubtype: Academic Journal
      doctype:
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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