PHBV/PCL microparticles for controlled release of resveratrol: physicochemical characterization, antioxidant potential, and effect on hemolysis of human erythrocytes.
Microparticles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) containing resveratrol were successfully prepared by simple emulsion/solvent evaporation. All formulations showed suitable encapsulation efficiency values higher than 80%. PHBV microparticles reveale...
| Publicado en: | Scientific World Journal pp. 542937 - 542938 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104455986&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104455986 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1537744X 1BX5 jtl: Scientific World Journal issn: 1537744X maglogo: N pubinfo: dt: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104455986 NLM22666135 2011572325 10.1100/2012/542937 NLM22666135 PMC3361330 104455986 ppf: 542937 ppct: 1 formats: tig: atl: PHBV/PCL microparticles for controlled release of resveratrol: physicochemical characterization, antioxidant potential, and effect on hemolysis of human erythrocytes. aug: au: Mendes, Jessica Bitencourt Emilio Riekes, Manoela Klüppel de Oliveira, Viviane Matoso Michel, Milton Domingos Stulzer, Hellen Karine Khalil, Najeh Maissar Zawadzki, Sônia Faria Mainardes, Rubiana Mara Farago, Paulo Vitor affil: Postgraduate Program in Pharmaceutical Sciences, Department of Pharmaceutical Sciences, State University of Ponta Grossa, 4748 Carlos Cavalcanti Avenue, 84030-900 Ponta Grossa, Brazil. sug: subj: Antioxidants Administration and Dosage Drug Delivery Systems Erythrocytes Drug Effects Hemolysis Drug Effects Polyesters Administration and Dosage Stilbenes Administration and Dosage Antioxidants Pharmacodynamics Calorimetry Microscopy, Electron, Scanning Particle Size Stilbenes Pharmacodynamics Chemistry, Analytical ab: Microparticles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) containing resveratrol were successfully prepared by simple emulsion/solvent evaporation. All formulations showed suitable encapsulation efficiency values higher than 80%. PHBV microparticles revealed spherical shape with rough surface and presence of pores. PCL microparticles were spherically shaped with smooth surface. Fourier-transformed infrared spectra demonstrated no chemical bond between resveratrol and polymers. X-ray powder diffraction patterns and differential scanning calorimetry analyses indicated that microencapsulation led to drug amorphization. These PHBV/PCL microparticles delayed the dissolution profile of resveratrol. Release profiles were better fitted to biexponential equation. The hypochlorous-acid-scavenging activity and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation discoloration assay confirmed that the antioxidant activity of PHBV/PCL microparticles was kept, but was dependent on the microparticle morphology and dissolution profile. Resveratrol-loaded PHBV/PCL microparticles showed no cytotoxic effect on red blood cells. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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