Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study.
Background: An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.Objectives: We assessed the association between POPs and the odds of an endometriosis diagnosis and the consi...
| Published in: | Environmental Health Perspectives Vol. 120; no. 6; pp. 811 - 817 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
National Institute of Environmental Health Sciences
Jun2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104462008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104462008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Jun2012 vid: 120 iid: 6 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104462008 76457070 10.1289/ehp.1104432 NLM22417635 104462008 ppf: 811 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study. aug: au: Buck Louis, Germaine M. Zhen Chen Peterson, C. Matthew Hediger, Mary L. Croughan, Mary S. Sundaram, Rajeshwari Stanford, Joseph B. Varner, Michael W. Fujimoto, Victor Y. Giudice, Linda C. Trumble, Ann Parsons, Patrick J. Kannan, Kurunthachalam affil: Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Health, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA sug: subj: Organic Chemicals Adverse Effects Environmental Pollutants Adverse Effects Endometriosis Risk Factors Risk Assessment Prospective Studies Human Female Adult Interviews Algorithms Organic Chemicals Blood Toxicity Tests Funding Source Descriptive Statistics T-Tests Chi Square Test Wilcoxon Rank Sum Test Nonparametric Statistics Logistic Regression Odds Ratio Confidence Intervals Sensitivity and Specificity Data Analysis Software Endometriosis Surgery Sampling Methods Endometriosis Diagnosis Adult: 19-44 years Female ab: Background: An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.Objectives: We assessed the association between POPs and the odds of an endometriosis diagnosis and the consistency of findings by biological medium and study cohort.Methods: Using a matched cohort design, we assembled an operative cohort of women 18–44 years of age undergoing laparoscopy or laparotomy at 14 participating clinical centers from 2007 to 2009 and a population-based cohort matched on age and residence within a 50-mile catchment area of the clinical centers. Endometriosis was defined as visualized disease in the operative cohort and as diagnosed by magnetic resonance imaging in the population cohort. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each POP in relation to an endometriosis diagnosis, with separate models run for each medium (omental fat in the operative cohort, serum in both cohorts) and cohort. Adjusted models included age, body mass index, breast-feeding conditional on parity, cotinine, and lipids.Results: Concentrations were higher in omental fat than in serum for all POPs. In the operative cohort, γ-hexachlorocyclohexane (γ-HCH) was the only POP with a significant positive association with endometriosis [per 1-SD increase in log-transformed γ-HCH: adjusted OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; β-HCH was the only significant predictor in the population cohort (per 1-SD increase in log-transformed β-HCH: AOR = 1.72; 95% CI: 1.09, 2.72) pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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