MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis.
Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC).Methods: Sixty-one consecutive patients were stratified by CPC (class A026; B020; C015) and compared with age-matched controls (n =...
| Publicado en: | European Radiology Vol. 22; no. 6; pp. 1224 - 1233 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104466253&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104466253 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2012 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104466253 NLM22302503 2011592478 10.1007/s00330-012-2378-5 NLM22302503 104466253 ppf: 1224 ppct: 9 formats: fmt: @attributes: type: P tig: atl: MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis. aug: au: Heye T Yang SR Bock M Brost S Weigand K Longerich T Kauczor HU Hosch W Heye, Tobias Yang, Schu-Ren Bock, Michael Brost, Sylvia Weigand, Kilian Longerich, Thomas Kauczor, Hans-Ulrich Hosch, Waldemar affil: Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany sug: subj: Algorithms Image Interpretation, Computer Assisted Methods Liver Cirrhosis Pathology Magnetic Resonance Imaging Methods Female Human Image Enhancement Methods Male Middle Age Reproducibility of Results Sensitivity and Specificity Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC).Methods: Sixty-one consecutive patients were stratified by CPC (class A026; B020; C015) and compared with age-matched controls (n = 31). Relaxometry measurements were performed at 1.5 T using six saturation recovery times (200-3,000 ms) to determine liver T1, six echo times (TE 14-113 ms) for T2 and eight TE (4.8-38 ms) for T2* assessment. Signal intensities in selected regions of interest in the liver parenchyma were fitted to theoretical models with least squares minimisation algorithms to determine T1, T2 and T2*.Results: The most significant difference was the higher T1 values (852 ± 132 ms) in cirrhotic livers compared with controls (678 ± 45 ms, P < 0.0001). A less significant difference was seen for T2* (23 ± 5 vs. 26 ± 7 ms). Subdifferentiation showed a statistically significant difference between control group and individual CPC classes as well as between class C and classes A or B for T1 relaxation times.Conclusion: Measurement of T1 relaxation time can differentiate healthy subjects from patients with liver cirrhosis, and can distinguish between mild/moderate disease (CPC A/B) and advanced disease (CPC C).Key Points: • Significantly elevated magnetic resonance T1 relaxation times are found in liver cirrhosis. • T1 relaxation times can distinguish healthy subjects from patients with liver cirrhosis. • T1 relaxation times can distinguish Child-Pugh classes Aand B from C. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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