Upper Airway Fat Tissue Distribution in Subjects With Obstructive Sleep Apnea and Its Effect on Retropalatal Mechanical Loads.
OBJECTIVE: To validate the hypothesis that fat tissue accumulation adjacent to the upper airway contributes to a predisposition to obstructive sleep apnea (OSA), irrespective of body mass index (BMI), as well as investigate the effect of the volume of fat tissue on pharyngeal mechanical loads. METHO...
| Publicado en: | Respiratory Care Vol. 57; no. 7; pp. 1098 - 1106 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104468135&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104468135 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Jul2012 vid: 57 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 104468135 77327484 10.4187/respcare.00929 NLM22273428 104468135 ppf: 1098 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Upper Airway Fat Tissue Distribution in Subjects With Obstructive Sleep Apnea and Its Effect on Retropalatal Mechanical Loads. aug: au: Yanru Li Na Lin Jingying Ye Qinglin Chang Demin Han Sperry, Al affil: Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China sug: subj: Sleep Apnea, Obstructive Pathology Tongue Pharynx Adipose Tissue Distribution Human Odds Ratio Magnetic Resonance Imaging Body Mass Index China Male Descriptive Statistics Scales Polysomnography Data Analysis Software Spearman's Rank Correlation Coefficient Paired T-Tests Unpaired T-Tests Logistic Regression Anthropometry Confidence Intervals Adult Middle Age Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male ab: OBJECTIVE: To validate the hypothesis that fat tissue accumulation adjacent to the upper airway contributes to a predisposition to obstructive sleep apnea (OSA), irrespective of body mass index (BMI), as well as investigate the effect of the volume of fat tissue on pharyngeal mechanical loads. METHODS: Fourteen subjects and 14 controls were enrolled in this study. Pharyngeal anatomy (the fat tissue volume in the retropalatal region and retroglossal region) were evaluated using magnetic resonance imaging. Whether the subjects had a segmental closing pressure higher than atmospheric pressure was determined by pharyngoscopy under general anesthesia. The difference in fat tissue distribution between subjects with OSA and BMI-matched controls was investigated. Fat tissue distributions in subjects with positive or negative segmental closing pressure were also compared. RESULTS: Significant differences occurred between controls and subjects with OSA in volumes of parapharyngeal fat pad (P = .001), fat of soft palate (P = .01), as well as proportion of the parapharyngeal fat pad to the volume of total lateral pharyngeal soft tissues (P = .004). The volume of pharyngeal cavity, neck circumference, and volume of subcutaneous fat tissues were not significantly different statistically. Volume of fat in soft palate (odds ratio 5.893) and parapharyngeal fat pad in retropalatal and retroglossal region (odds ratios 1.781 and 1.845) were significant predictors of OSA. The volume of fat in the soft palate (P = .003) and parapharyngeal fat pad (P = .002) was higher in participants with positive retropalatal closing pressure; participants with positive retroglossal closing pressure had increased volumes of the tongue (P = .02) and the parapharyngeal fat pad (P = .004). CONCLUSIONS: Patients with OSA have more fat tissue adjacent to the pharyngeal cavity than BMI-matched controls. Fats deposited around the upper airway may contribute to the collapsibility of retropalatal and retroglossal airway in both patients and controls. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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