New diffusion metrics for spondylotic myelopathy at an early clinical stage.
Objectives: To investigate the use of root mean square displacement (RMSD) and mean diffusional kurtosis (DK) metrics of q-space imaging data to estimate spinal cord compression in patients with early cervical spondylosis.Methods: We studied 50 consecutive patients at our institution (22 male, 28 fe...
| Publicado en: | European Radiology Vol. 22; no. 8; pp. 1797 - 1803 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104472377&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104472377 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2012 vid: 22 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104472377 NLM22411307 2011603963 10.1007/s00330-012-2410-9 NLM22411307 PMC3387361 104472377 ppf: 1797 ppct: 6 formats: fmt: @attributes: type: P tig: atl: New diffusion metrics for spondylotic myelopathy at an early clinical stage. aug: au: Hori M Fukunaga I Masutani Y Nakanishi A Shimoji K Kamagata K Asahi K Hamasaki N Suzuki Y Aoki S Hori, Masaaki Fukunaga, Issei Masutani, Yoshitaka Nakanishi, Atsushi Shimoji, Keigo Kamagata, Koji Asahi, Koichi Hamasaki, Nozomi Suzuki, Yuriko Aoki, Shigeki affil: Department of Radiology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan sug: subj: Spinal Cord Diseases Diagnosis Spondylosis Diagnosis Adult Aged Aged, 80 and Over Diffusion Magnetic Resonance Imaging Methods Female Image Processing, Computer Assisted Male Middle Age Statistics Spinal Cord Pathology Spinal Cord Compression Pathology Spinal Cord Diseases Pathology Spinal Osteophytosis Pathology Spondylosis Pathology Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: To investigate the use of root mean square displacement (RMSD) and mean diffusional kurtosis (DK) metrics of q-space imaging data to estimate spinal cord compression in patients with early cervical spondylosis.Methods: We studied 50 consecutive patients at our institution (22 male, 28 female; mean age 58 years; age range 20-86 years) who had clinical signs and symptoms suggestive of early clinical stage cervical myelopathy. After conventional magnetic resonance (MR) imaging, diffusion tensor and q-space image data were acquired using 3-T MR imaging. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), RMSD and mean DK values were calculated and compared between compressed and uncompressed spinal cords.Results: FA and mean DK values were significantly lower and RMSD was significantly higher (P = 0.0060, 0.0020 and 0.0062, respectively; Mann-Whitney U test with the Bonferroni correction) in compressed spinal cords than in uncompressed cords. ADC was also higher in compressed cords, but this difference was not statistically significant.Conclusions: In the evaluation of spinal cord damage in early cervical spondylosis, mean DK and RMSD values in the spinal cord may be highly sensitive indicators of microstructural change and damage.Key Points: • Absolute surgical indications for cervical spondylosis with myelopathy remain to be established. • Diffusion tensor MRI shows abnormalities in normal-appearing but compressed spinal cord. • Non-Gaussian diffusion analysis is highly sensitive in revealing spinal cord damage. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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