Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method.
Objectives: To investigate how the histological scoring of microvessel density affects correlations between integrated (18)F-FDG-PET/perfusion CT parameters and CD105 microvessel density.Methods: A total of 53 patients were enrolled from 2007 to 2010. Integrated (18)F-FDG-PET/perfusion CT was succes...
| Publicado en: | European Radiology Vol. 22; no. 8; pp. 1687 - 1693 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104472391&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104472391 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2012 vid: 22 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104472391 NLM22527369 2011603977 10.1007/s00330-012-2423-4 NLM22527369 104472391 ppf: 1687 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method. aug: au: Goh V Rodriguez-Justo M Engledow A Shastry M Endozo R Peck J Meagher M Taylor SA Halligan S Groves AM Goh, Vicky Rodriguez-Justo, Manuel Engledow, Alec Shastry, Manu Endozo, Raymondo Peck, Jacqui Meagher, Marie Taylor, Stuart A Halligan, Steve Groves, Ashley M affil: Division of Imaging Sciences & Biomedical Engineering, King's College London, London, UK sug: subj: Colorectal Neoplasms Pathology Aged Aged, 80 and Over Algorithms Antigens, Surface Colorectal Neoplasms Blood Supply Female Fludeoxyglucose F 18 Pharmacodynamics Immunohistochemistry Methods Male Microcirculation Middle Age Neoplasm Metastasis Perfusion Phenotype Tomography, Emission-Computed Methods Receptors, Cell Surface Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: To investigate how the histological scoring of microvessel density affects correlations between integrated (18)F-FDG-PET/perfusion CT parameters and CD105 microvessel density.Methods: A total of 53 patients were enrolled from 2007 to 2010. Integrated (18)F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUV(max), SUV(mean) and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman's rank correlation.Results: Mean (SD) for tumour size was 38.5 (20.5) mm, for SUV(max), SUV(mean) and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUV(max) or SUV(mean)) and CD105 expression (r = 0.08-0.22, P = 0.21-0.63).Conclusions: The histological analysis method affects correlations between tumour CD105 expression and BF but not SUV(max) or SUV(mean).Key Points: • FDG-PET/perfusion CT offers new surrogate biomarkers of angiogenesis. • Microvessel density scoring influences histopathological correlations with CT blood flow. • Highest correlations were found with the Chalkley analysis method. • Correlations between SUV and CD105 are not affected by the scoring method. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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