Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline.
Objective: The aim of this study was to compare the impact of nortriptyline to sertraline on change in cognitive functioning in depressed older adults.Methods: We used pre-post neuropsychological data collected as part of a 12-week medication trial comparing sertraline to nortriptyline in the treatm...
| Publicado en: | International Journal of Geriatric Psychiatry Vol. 27; no. 8; pp. 777 - 785 |
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| Autores principales: | , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104472770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104472770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08856230 BWG jtl: International Journal of Geriatric Psychiatry issn: 08856230 maglogo: Y pubinfo: dt: Aug2012 vid: 27 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104472770 NLM21919060 2011605219 10.1002/gps.2783 NLM21919060 PMC3391314 104472770 ppf: 777 ppct: 8 formats: tig: atl: Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline. aug: au: Culang-Reinlieb ME Sneed JR Keilp JG Roose SP Culang-Reinlieb, Michelle E Sneed, Joel R Keilp, John G Roose, Steven P affil: Graduate Center, City University of New York, New York, NY, USA sug: subj: Adrenergic Uptake Inhibitors Therapeutic Use Antidepressive Agents Therapeutic Use Cognition Drug Effects Depression Drug Therapy Nortriptyline Therapeutic Use Serotonin Uptake Inhibitors Therapeutic Use Sertraline Hydrochloride Therapeutic Use Aged Attention Drug Effects Depression Physiopathology Double-Blind Studies Female Human Male Memory Drug Effects Mental Processes Drug Effects Middle Age Psychomotor Performance Drug Effects Randomized Controlled Trials Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: The aim of this study was to compare the impact of nortriptyline to sertraline on change in cognitive functioning in depressed older adults.Methods: We used pre-post neuropsychological data collected as part of a 12-week medication trial comparing sertraline to nortriptyline in the treatment of older adults with non-psychotic, unipolar major depression to examine change in cognitive functioning. Neuropsychological assessments included mental status (Mini-Mental Status Exam), psychomotor speed (Purdue Pegboard), attention (Continuous Performance Test, Trail Making Test A), executive functioning (Stroop Color/word Test, Trail Making Test B), and memory (Buschke Selective Reminding Test).Results: Within treatment groups, patients treated with sertraline improved only on verbal learning. This change did not depend on responder status. Between treatment groups, patients treated with sertraline improved more in verbal learning compared with patients treated with nortriptyline. Looking at change in cognition as a function of medication condition and responder status revealed that sertraline responders improved more in verbal learning compared with nortriptyline responders but not more than sertraline non-responders or nortriptyline non-responders. Nortriptyline responders were the only treatment by responder status group to show no improvement in verbal learning from baseline to endpoint.Conclusions: Unexpectedly, nortriptyline responders showed no improvement in verbal learning as compared with patients treated with sertraline or nortriptyline non-responders. However, given the small sample sizes and number of statistical tests (potential for type 1 error), replication is warranted. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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