Discordant Impairment of Multidirectional Myocardial Deformation in Rats with Doxorubicin Induced Cardiomyopathy.
Background: In doxorubicin-induced cardiomyopathy (DIC), the sequence of decrease in multidirectional myocardial deformation has not been clearly elucidated. Objectives: We investigated the sequence of myocardial deformations in rat DIC, using two-dimensional speckle tracking echocardiography (2DSTE...
| Publicado en: | Echocardiography Vol. 29; no. 6; pp. 720 - 729 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104473434&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104473434 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Jul2012 vid: 29 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104473434 77569244 10.1111/j.1540-8175.2012.01689.x NLM22486544 104473434 ppf: 720 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Discordant Impairment of Multidirectional Myocardial Deformation in Rats with Doxorubicin Induced Cardiomyopathy. aug: au: Kim, Yong-Hyun Kim, Mina Park, Seong-Mi Kim, Seong Hwan Lim, Sang Yup Ahn, Jeong-Cheon Song, Woo-Hyuk Shim, Wan-Joo affil: Division of Cardiology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea sug: subj: Cardiomyopathy, Hypertrophic Chemically Induced Doxorubicin Administration and Dosage Myocardium Physiopathology Echocardiography Methods Animal Studies Rats Control Group Correlational Studies Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Mann-Whitney U Test Kruskal-Wallis Test Wilcoxon Signed Rank Test Descriptive Statistics Data Analysis Software ab: Background: In doxorubicin-induced cardiomyopathy (DIC), the sequence of decrease in multidirectional myocardial deformation has not been clearly elucidated. Objectives: We investigated the sequence of myocardial deformations in rat DIC, using two-dimensional speckle tracking echocardiography (2DSTE). Methods: Twenty rats were treated with doxorubicin (1.25 mg/kg × 16 times, intraperitoneal) for 4 weeks and compared with nine control rats. Myocardial strain analysis with 2DSTE, as well as conventional echocardiography, was obtained. Results: Compared with baseline, longitudinal strain/strain rate (LS/LSr) decreased at week 2 (−15.7 ± 1.5 to −14.1 ± 1.4%, P = 0.01 for LS; −4.4 ± 0.7 to −3.9 ± 0.5 per second, P = 0.009 for LSr). Left ventricular ejection fraction (LVEF) and circumferential strain (CS) decreased at week 4 (80.3 ± 3.2 to 78.1 ± 3.3%, P = 0.031 for LVEF; −18.6 ± 1.9 to −15.0 ± 3.4%, P = 0.019 for CS). Circumferential strain rate (CSr) decreased at week 6 (−5.5 ± 0.8 to −4.6 ± 1.0 per second, P = 0.008). Radial strain/strain rate (RS/RSr) decreased at week 8 (54.8 ± 9.4 to 43.7 ± 10.6%, P = 0.005 for RS; 8.0 ± 1.1 to 7.0 ± 1.1 per second, P = 0.005 for RSr), while there was no significant change in LS/LSr, LVEF, CS/CSr, or RS/RSr in the control group. LVEF had the highest correlation with LS (r =−0.607, P = 0.000) and the lowest correlation with RSr (r = 0.357, P = 0.000). Conclusions: In DIC of rat hearts, LS/LSr decreased first, and then LVEF, CS, CSr, RS/RSr subsequently decreased. LS/LSr is considered to be a more sensitive predictor than LVEF in progressive rat DIC, and RS/RSr was preserved until the last stage. (Echocardiography 2012;29:720-728) pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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