Loss of cellular viability in areas of ground-glass opacity on computed tomography images immediately after pulmonary radiofrequency ablation in rabbits.
Purpose: To determine cellular viability of lung parenchyma and neoplastic cells in areas of ground-glass opacity (GGO) on computed tomography (CT) images immediately after pulmonary radiofrequency ablation (RFA) in rabbits.Materials and Methods: A LeVeen RFA electrode was placed percutaneously into...
| Publicado en: | Japanese Journal of Radiology Vol. 30; no. 4; pp. 323 - 331 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104476107&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104476107 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: May2012 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104476107 NLM22302295 2011612464 10.1007/s11604-012-0054-y NLM22302295 104476107 ppf: 323 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Loss of cellular viability in areas of ground-glass opacity on computed tomography images immediately after pulmonary radiofrequency ablation in rabbits. aug: au: Kuroki M Nakada H Yamashita A Sawaguchi A Uchino N Sato S Asanuma T Asada Y Tamura S Kuroki, Masaomi Nakada, Hiroshi Yamashita, Atsushi Sawaguchi, Akira Uchino, Noriko Sato, Shinya Asanuma, Taketoshi Asada, Yujiro Tamura, Shozo affil: Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan sug: subj: Catheter Ablation Methods Lung Neoplasms Radiography Lung Neoplasms Surgery Tomography, X-Ray Computed Analysis of Variance Animals Catheter Ablation Equipment and Supplies Cell Physiology Equipment Design Fluoroscopy Lung Neoplasms Pathology Prospective Studies Rabbits Staining and Labeling ab: Purpose: To determine cellular viability of lung parenchyma and neoplastic cells in areas of ground-glass opacity (GGO) on computed tomography (CT) images immediately after pulmonary radiofrequency ablation (RFA) in rabbits.Materials and Methods: A LeVeen RFA electrode was placed percutaneously into rabbit lungs with or without metastatic VX2 tumors. Five minutes later, seven isolated lungs were imaged by use of a multi-detector row CT scanner, and the images were compared with histological features. The cellular viability of the lung tissues was assessed by nicotinamide adenine dinucleotide hydrogen (NADH) staining in eight normal lungs and in three lungs with multiple metastatic tumors.Results: All lung lesions appeared as bilayered structures with a central, dense, attenuated area and an outer area of GGO on CT images, and as three-layered structures on macroscopic and microscopic images 5 min after RFA. The GGO areas approximately corresponded to the outer two layers in macroscopic images that were exudative and congestive on microscopic images. Staining for NADH was significantly reduced in the GGO and densely attenuated areas with or without tumor tissue staining compared with the non-ablated area.Conclusions: Our results suggest that an area of GGO that appears on CT immediately after RFA can be effectively treated by RFA. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|