Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia.
Background: Helicobacter species associated with human infection include Helicobacter pylori, Helicobacter heilmannii and Helicobacter felis among others. In this study we determined the prevalence of H. pylori and non-Helicobacter pylori organisms H. felis and H. heilmannii and analyzed the associa...
| Publicado en: | BMC Gastroenterology Vol. 12; no. 1; pp. 3 - 4 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104491905&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104491905 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2012 vid: 12 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104491905 104491905 NLM22226326 2011641013 10.1186/1471-230X-12-3 NLM22226326 PMC3276444 104491905 ppf: 3 ppct: 1 formats: tig: atl: Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia. aug: au: Yakoob, Javed Abbas, Zaigham Khan, Rustam Naz, Shagufta Ahmad, Zubair Islam, Muhammad Awan, Safia Jafri, Fatima Jafri, Wasim affil: Department of Medicine, The Aga Khan University, Karachi, Pakistan. yakoobjaved@hotmail.com sug: subj: Dyspepsia Epidemiology Helicobacter Infections Epidemiology Helicobacter Helicobacter Pylori Adolescence Adult Aged Animals Biopsy Cats Comorbidity Disease Susceptibility Epidemiology Dogs Female Gastric Mucosa Microbiology Gastric Mucosa Pathology Helicobacter Infections Microbiology Human Male Middle Age Documentation Pets Prevalence Retrospective Design Risk Factors Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Helicobacter species associated with human infection include Helicobacter pylori, Helicobacter heilmannii and Helicobacter felis among others. In this study we determined the prevalence of H. pylori and non-Helicobacter pylori organisms H. felis and H. heilmannii and analyzed the association between coinfection with these organisms and gastric pathology in patients presenting with dyspepsia. Biopsy specimens were obtained from patients with dyspepsia on esophagogastroduodenoscopy (EGD) for rapid urease test, histology and PCR examination for Helicobacter genus specific 16S rDNA, H. pylori phosphoglucosamine mutase (glmM) and urease B (ureB) gene of H. heilmannii and H. felis. Sequencing of PCR products of H. heilmannii and H. felis was done.Results: Two hundred-fifty patients with dyspepsia were enrolled in the study. The mean age was 39 ± 12 years with males 162(65%). Twenty-six percent (66 out of 250) were exposed to cats or dogs. PCR for Helicobacter genus specific 16S rDNA was positive in 167/250 (67%), H. pylori glmM in 142/250 (57%), H. heilmannii in 17/250 (6%) and H. felis in 10/250 (4%), respectively. All the H. heilmannii and H. felis PCR positive patients were also positive for H. pylori PCR amplification. The occurrence of coinfection of H. pylori and H. heilmannii was 17(6%) and with H. felis was 10(4%), respectively. Only one out of 66 exposed to pets were positive for H. heilmannii and two for H. felis. Histopathology was carried out in 160(64%) of 250 cases. Chronic active inflammation was observed in 53(56%) (p = 0.001) of the patients with H. pylori infection alone as compared to 3(37%) (p = 0.73) coinfected with H. heilmannii and H. pylori and 3(60%) coinfected with H. felis and H. pylori (p = 0.66). Intestinal metaplasia was observed in 3(3%)(p = 1.0) of the patients with H. pylori infection alone as compared to 2(25%) (p = 0.02) coinfected with H. heilmannii and H. pylori and 1(20%) coinfected with H. felis and H. pylori (p = 0.15).Conclusion: The prevalence of H. heilmannii and H. felis was low in our patients with dyspepsia. Exposure to pets did not increase the risk of H. heilmannii or H. felis infection. The coinfection of H. pylori with H. heilmannii was seen associated with intestinal metaplasia, however this need further confirmation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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